This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Eva Schielke, MD; Klaus Tatsch, MD; Hans Walter Pfister, MD; Claudia Trenkwalder, MD; Gerda Leinsinger, MD; Carl Martin Kirsch, MD; Alexander Matuschke, MD; Karl Max Einhäupl, MD

Arch Neurol. 1990;47(12):1342-1345.

Abstract
• In order to determine if brain perfusion abnormalities, which are known in patients with acquired immunodeficiency syndrome dementia, occur in early stages of human immunodeficiency virus infection, technetium 99m hexamethyl-propyleneamine oxime-single-photon emission computed tomography studies were performed in 20 patients infected with human immunodeficiency virus who belonged to Walter Reed stages I through IV. None of these patients demonstrated signs of dementia or severe neurological dysfunction. Pathological patterns of hexamethyl-propyleneamine oxime uptake were seen in 14 patients, seven of whom had normal results during neurological examination. Only four patients had signs of cerebral atrophy on cranial computed tomographic scan. These data suggest that subtle changes in cerebral perfusion seem to arise early in the course of human immunodeficiency virus infection and may indicate human immunodeficiency virus encephalopathy before neurological symptoms or noticeable structural damage occurs.

Author Affiliations
From the Departments of Neurology (Drs Schielke, Pfister, Trenkwalder, and Einhäupl) and Radiology, Division of Nuclear Medicine (Drs Tatsch, Leinsinger, and Kirsch), Klinikum Grosshadern; and the Department of Internal Medicine, Medizinische Poliklinik (Dr Matuschke), University of Munich (Federal Republic of Germany).

Footnotes
Accepted for publication May 11, 1990.

Reprint requests to Department of Neurology, Klinikum Grosshadern, University of Munich, Marchioninstrasse 15, 8000 Munich 70, Federal Republic of Germany (Dr Schielke).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Resting cerebral blood flow: A potential biomarker of the effects of HIV in the brain
Ances et al.
Neurology 2009;73:702-708.
ABSTRACT | FULL TEXT  

Perfusion MRI detects rCBF abnormalities in early stages of HIV-cognitive motor complex
Chang et al.
Neurology 2000;54:389-389.
ABSTRACT | FULL TEXT  

Blood-Brain Barrier Tight Junction Disruption in Human Immunodeficiency Virus-1 Encephalitis
Dallasta et al.
Am. J. Pathol. 1999;155:1915-1927.
ABSTRACT | FULL TEXT  

Influence of Cognitive Reserve on Neuropsychological Functioning in Asymptomatic Human Immunodeficiency Virus-1 Infection
Stern et al.
Arch Neurol 1996;53:148-153.
ABSTRACT