This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Longitudinal Course, Neuropsychological Profile, and Language Features

Sandra Weintraub, PhD; Nan P. Rubin, MS; M.-Marsel Mesulam, MD

Arch Neurol. 1990;47(12):1329-1335.

Abstract
• Four patients with the clinical syndrome of primary progressive aphasia and a nonfluent aphasia profile were followed up over a period of 3 to 5 years. Extensive neuropsychological data for three patients revealed a progressive, quantitative decline of language with relative stability of memory, visuospatial skills, and reasoning. Comportment and most activities of daily living were preserved even when speech was unintelligible. Although several aphasia types may be associated with primary progressive aphasia, a nonfluent aphasia profile and phonemic paraphasic errors are most useful in differentiating it from the much more common clinical syndrome, "probable Alzheimer's disease." The clinicopathological correlates of probable Alzheimer's disease differ from those associated with primary progressive aphasia. Therefore, the clinical distinction between the two syndromes may be important for predicting the underlying pathophysiologic changes during the life of the patient.

Author Affiliations
From the Division of Behavioral Neuroscience and Behavioral Neurology and the Charles A. Dana Research Institute, Beth Israel Hospital and Harvard Medical School, Boston, Mass.

Footnotes
Accepted for publication July 29, 1990.

Presented, in part, at the 18th annual meeting of the International Neuropsychological Society, Orlando, Fla, February 15, 1990, and at the 28th meeting of the Academy of Aphasia, Baltimore, Md, October 21, 1990.

Reprint requests to Behavioral Neurology Unit, Beth Israel Hospital, 330 Brookline Ave, Boston, MA 02215 (Dr Weintraub).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Neurology of anomia in the semantic variant of primary progressive aphasia
Mesulam et al.
Brain 2009;132:2553-2565.
ABSTRACT | FULL TEXT  

The logopenic/phonological variant of primary progressive aphasia
Gorno-Tempini et al.
Neurology 2008;71:1227-1234.
ABSTRACT | FULL TEXT  

PRIMARY PROGRESSIVE APHASIA: QUANTITATIVE ANALYSIS
Arzy et al.
Neurology 2008;71:145-146.
FULL TEXT  

Neuropsychiatric Symptoms in Behavioral Variant Frontotemporal Dementia and Primary Progressive Aphasia
Banks and Weintraub
J Geriatr Psychiatry Neurol 2008;21:133-141.
ABSTRACT  

Depression in Primary Progressive Aphasia
Medina and Weintraub
J Geriatr Psychiatry Neurol 2007;20:153-160.
ABSTRACT  

Semantic dementia and fluent primary progressive aphasia: two sides of the same coin?
Adlam et al.
Brain 2006;129:3066-3080.
ABSTRACT | FULL TEXT  

Clinicopathological and imaging correlates of progressive aphasia and apraxia of speech
Josephs et al.
Brain 2006;129:1385-1398.
ABSTRACT | FULL TEXT  

Natural history of primary progressive aphasia
Le Rhun et al.
Neurology 2005;65:887-891.
ABSTRACT | FULL TEXT  

Subscores of the FAB differentiate frontotemporal lobar degeneration from AD
Lipton et al.
Neurology 2005;65:726-731.
ABSTRACT | FULL TEXT  

A longitudinal study of sentence comprehension difficulty in primary progressive aphasia
Grossman and Moore
J. Neurol. Neurosurg. Psychiatry 2005;76:644-649.
ABSTRACT | FULL TEXT  

What's in a name: voxel-based morphometric analyses of MRI and naming difficulty in Alzheimer's disease, frontotemporal dementia and corticobasal degeneration
Grossman et al.
Brain 2004;127:628-649.
ABSTRACT | FULL TEXT  

Progressive non-fluent aphasia is associated with hypometabolism centred on the left anterior insula
Nestor et al.
Brain 2003;126:2406-2418.
ABSTRACT | FULL TEXT  

Primary Progressive Aphasia -- A Language-Based Dementia
Mesulam
NEJM 2003;349:1535-1542.
FULL TEXT  

Clinicopathologic Case Report: Progressive Aphasia in a 77-Year-Old Man
Clark et al.
J. Neuropsychiatry Clin. Neurosi. 2003;15:231-238.
FULL TEXT  

Slowly progressive aphasia with striatal involvement
Nagaratnam et al.
AM J ALZHEIMERS DIS OTHER DEMEN 2002;17:18-22.
ABSTRACT  

Primary progressive aphasia: A review of the neourobiology of a common presentation of Pick complex
Kertesz and Munoz
AM J ALZHEIMERS DIS OTHER DEMEN 2002;17:30-36.
ABSTRACT  

Frontotemporal dementia (Pick's disease): Clinical features and assessment
Hodges
Neurology 2001;56:S6-10.
ABSTRACT | FULL TEXT  

Corticobasal ganglionic degeneration and/or frontotemporal dementia? A report of two overlap cases and review of literature
Mathuranath et al.
J. Neurol. Neurosurg. Psychiatry 2000;68:304-312.
ABSTRACT | FULL TEXT  

Slowly progressive aphasia heralding dementia
Nagaratnam and Nagaratnam
AM J ALZHEIMERS DIS OTHER DEMEN 1997;12:245-251.
ABSTRACT  

Neuropsychological Patterns and Language Deficits in 20 Consecutive Cases of Autopsy-Confirmed Alzheimer's Disease
Price et al.
Arch Neurol 1993;50:931-937.
ABSTRACT  

Profiles of Language Impairment in Primary Progressive Aphasia
Karbe et al.
Arch Neurol 1993;50:193-201.
ABSTRACT  

Progressive Amusia and Aprosody
Confavreux et al.
Arch Neurol 1992;49:971-976.
ABSTRACT  

The Role of Brain Single Photon Emission Computed Tomography in the Diagnosis of Primary Progressive Aphasia
McDaniel et al.
Arch Neurol 1991;48:1257-1260.
ABSTRACT  

Progressive Nonfluent Aphasia With Dementia: A Case Report
Feher et al.
J Geriatr Psychiatry Neurol 1991;4:236-240.
ABSTRACT