This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

18-Month Results

C. W. Olanow, MD, FRCPC; W. Koller, MD, PhD; C. G. Goetz, MD; G. T. Stebbins, PhD; D. W. Cahill, MD; L. L. Gauger; R. Morantz, MD; R. D. Penn, MD; C. M. Tanner, MD; H. L. Klawans, MD; K. M. Shannon, MD; C. L. Comella, MD; T. Witt, MD

Arch Neurol. 1990;47(12):1286-1289.

Abstract
• Eighteen of 19 patients who underwent autologous adrenal medullary transplantation to the right caudate nucleus have been followed up for 18 months. During the course of this study, a statistically significant improvement was noted in percent "on" time, percent "on" time without dyskinesia, activity of daily living (ADL) scores during the "on" stages, and ADL, motor, and Schwab-England scores during the "off" stages. Benefits tended to be maximal at 6 months and to gradually lessen thereafter, although statistically significant improvement in comparison with baseline was still present at 18 months for ADL, motor, and Hoehn-Yahr scores during the "off" stages. Almost all parameters had deteriorated by 18 months compared with 12 months, including those remaining significantly improved in comparison with baseline. These patterns were similar for each of the three participating centers. Complications were largely restricted to the perioperative period.

Author Affiliations
From the Departments of Neurology, University of South Florida, Tampa (Drs Olanow and Cahill and Ms Gauger), University of Kansas, Kansas City (Drs Koller and Morantz), and Rush-Presbyterian St Luke's Medical Center, Chicago, Ill (Drs Goetz, Stebbins, Penn, Tanner, Klawans, Shannon, Comella, and Witt).

Footnotes
Accepted for publication August 1, 1990.

Reprint requests to Department of Neurology, University of South Florida, 4 Columbia Dr, Suite 410, Tampa, FL 33606 (Dr Olanow).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Pathologic findings in retinal pigment epithelial cell implantation for Parkinson disease
Farag et al.
Neurology 2009;73:1095-1102.
ABSTRACT | FULL TEXT  

Present and future directions in the management of motor complications in patients with advanced PD
Olanow
Neurology 2003;61:S24-33.
FULL TEXT  

Use of Placebo Surgery in Controlled Trials of a Cellular-Based Therapy for Parkinson's Disease
Freeman et al.
NEJM 1999;341:988-992.
FULL TEXT  

Progenitor Cell Biology: Implications for Neural Regeneration
Mehler and Kessler
Arch Neurol 1999;56:780-784.
ABSTRACT | FULL TEXT  

Switching dopamine agonists in advanced Parkinson's disease: Is rapid titration preferable to slow?
Goetz et al.
Neurology 1999;52:1227-1227.
ABSTRACT | FULL TEXT  

Understanding Parkinson Disease
Cummings
JAMA 1999;281:376-378.
FULL TEXT  

Parkinson's Disease- Second of Two Parts
Lang and Lozano
NEJM 1998;339:1130-1143.
FULL TEXT  

A 61-Year-Old Man With Parkinson's Disease-Reply
Olanow
JAMA 1996;276:104-104.
ABSTRACT  

Fetal-Tissue Transplantation for Parkinson's Disease
Goetz et al.
NEJM 1993;329:1498-1500.
FULL TEXT