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Peter C. Williamson, MD; Harold Merskey, DM; Sandra Morrison, MA; Kiran Rabheru, MD; Hannah Fox, MB; Kim Wands; Cindy Wong, MSc; Vladimir Hachinski, MD

Arch Neurol. 1990;47(11):1185-1188.

Abstract
• We obtained a topographic computer analysis of the electroencephalogram in 53 normal elderly subjects. Normal aging was not associated with an increase in slow (delta) activity. However, cognitive performance correlated positively with fast (beta) activity particularly in frontal leads, even after controlling for age, education, occupation, and medication. Five subjects who showed early signs of cognitive decline, had all a marked reduction in beta activity suggesting that this may be an early indication of intellectual loss.

Author Affiliations
From the London (Canada) Psychiatric Hospital (Drs Williamson and Merskey, and Ms Wands); University of Western Ontario (Drs Williamson, Merskey, Rabheru, and Hachinski, and Mss Morrison and Fox); University Hospital (Dr Hachinski); and Robarts Research Institute (Drs Merskey and Hachinski, and Ms Wong), Ontario, Canada.

Footnotes
Accepted for publication May 11, 1990.

Reprint requests to the London Psychiatric Hospital, 850 Highbury Ave, London, Ontario, Canada N6A 4H1 (Dr Williamson).

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