Brain imaging abnormalities in mental disorders of late life
G. S. Zubenko, P. Sullivan, J. P. Nelson, S. H. Belle, F. J. Huff and G. L. Wolf
Department of Psychiatry, University of Pittsburgh, PA.
Psychiatric inpatients with dementia (N = 61) or depression (N = 67) in
late life were 2.6 times more likely to manifest magnetic resonance imaging
abnormalities of the brain than were elderly controls (N = 44). Controlling
for the effects of age and gender, demented patients were distinguishable
from controls by an increased prevalence of cortical atrophy and
infarction, while depressed patients exhibited an increased prevalence of
cortical infarctions and leukoencephalopathy. Patients with dementia were
distinguishable from those with major depression by an increased prevalence
of cortical atrophy. These results indicate that major depression in late
life, like dementia, is associated with a remarkable increase in overt
pathologic changes in the brain.
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