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George S. Zubenko, MD, PhD; Patrick Sullivan, MD; John P. Nelson, MD; Steven H. Belle, PhD; F. Jacob Huff, MD; Gerald L. Wolf, MD, PhD

Arch Neurol. 1990;47(10):1107-1111.

Abstract
• Psychiatric inpatients with dementia (N = 61) or depression (N = 67) in late life were 2.6 times more likely to manifest magnetic resonance imaging abnormalities of the brain than were elderly controls (N = 44). Controlling for the effects of age and gender, demented patients were distinguishable from controls by an increased prevalence of cortical atrophy and infarction, while depressed patients exhibited an increased prevalence of cortical infarctions and leukoencephalopathy. Patients with dementia were distinguishable from those with major depression by an increased prevalence of cortical atrophy. These results indicate that major depression in late life, like dementia, is associated with a remarkable increase in overt pathologic changes in the brain.

Author Affiliations
From Geriatric Health Services, Department of Psychiatry (Drs Zubenko, Sullivan, Nelson, and Huff), Department of Neurology (Dr Huff), and Department of Radiology (Dr Wolf), School of Medicine, and the Department of Epidemiology, Graduate School of Public Health (Dr Belle), University of Pittsburgh (Pa); and the Pittsburgh NMR Institute (Dr Wolf).

Footnotes
Accepted for publication March 16, 1990.

Reprint requests to Western Psychiatric Institute and Clinic, 3811 O'Hara St, Room E-1230, Pittsburgh, PA 15213 (Dr Zubenko).

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