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No Evidence for Human T-cell Leukemia Virus Type I or Human T-cell Leukemia Virus Type II Infection in Patients With Multiple Sclerosis
A. Perl, MD, PhD;
K. Nagy, MD;
T. Pazmany, PhD;
C. Isaacs;
K. Baraczka, MD;
T. Szabo, MD;
J. Feher, MD
Arch Neurol. 1990;47(10):1061-1063.
Abstract
• The involvement of human T-cell leukemia viruses (HTLVs) in the pathogenesis of 18 Hungarian patients with multiple sclerosis was investigated. No antibody to HTLVs could be detected in any of the patients. Furthermore, using polymerase chain reaction under highly sensitive conditions, neither HTLV-I DNA nor HTLV-II DNA could be noted in peripheral blood lymphocytes of the patients. Our data do not support a causal association of HTLV-I or HTLV-II with multiple sclerosis.
Author Affiliations
From the Second Department of Medicine, Semmelweis University (Drs Perl, Pazmany, Baraczka, and Szabo), MTA-IKI (Dr Nagy), and Department of Neurology, Weil Emil Hospital (Dr Baraczka), Budapest, Hungary; and the Department of Molecular Medicine and Immunology, Roswell Park Memorial Institute, Buffalo, NY (Drs Perl and Isaacs).
Footnotes
Accepted for publication June 22, 1990.
Reprint requests to Department of Molecular Medicine and Immunology, Roswell Park Memorial Institute, Buffalo, NY 14263 (Dr Perl).
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