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Acute Relapsing Guillain-Barré Syndrome After Long Asymptomatic Intervals
Eelco F. M. Wijdicks, MD;
Allan H. Ropper, MD
Arch Neurol. 1990;47(1):82-84.
Abstract
• Five patients who recovered from an initial episode of Guillain-Barré syndrome had acute relapses 4, 10, 15, 17, and 36 years later, respectively. Two patients had multiple subsequent relapses. The antecedent illnesses, distribution of weakness, and clinical courses of each relapse were similar for each patient, except that relapses in three patients were briefer than the initial episode. One patient had asymptomatic sarcoidosis. Pharyngeal, oculomotor, and diaphragmatic weakness requiring a ventilator were common. Complete recovery or mild residual deficits, return of reflexes, normal cerebrospinal fluid protein at the onset of recurrent episodes, and normal or virtually normal nerve conduction velocities at various times distinguished these patients from those with more typical chronic relapsing inflammatory polyneuropathy.
Author Affiliations
From the Neurological/Neurosurgical Intensive Care Unit, Massachusetts General Hospital, Boston.
Footnotes
Accepted for publication July 11, 1989.
Presented at the 41st annual meeting of the American Academy of Neurology, Chicago, Ill, April 1989.
Reprint requests to Department of Neurology, Massachusetts General Hospital, Boston, MA 02114 (Dr Ropper).
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