This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

A Case-Control Study Following Detection of a Cluster in a Small Wisconsin Community

Dean G. Sienko, MD; Jeffrey P. Davis, MD; Jack A. Taylor, MD; Benjamin R. Brooks, MD

Arch Neurol. 1990;47(1):38-41.

Abstract
• From 1975 to 1983, six cases of amyotrophic lateral sclerosis (ALS) were diagnosed in long-term residents of Two Rivers, Wis; the probability that this occurred due to chance was less than.05. To investigate potential risk factors for ALS, we conducted a case-control study using two control subjects matched to each case patient for age, gender, and duration of residence in Two Rivers. Physical trauma, the frequent consumption of freshly caught Lake Michigan fish, and a family history of cancer were reported more often by case patients than control subjects. These findings support previous studies proposing a role for trauma in ALS pathogenesis and suggest that the causative role of diet should be further explored. Continued surveillance for and epidemiologic investigation of ALS clusters with subsequent retrospective analysis may provide clues concerning the cause of ALS.

Author Affiliations
From the Bureau of Community Health and Prevention, Wisconsin Division of Health (Drs Sienko, Davis, and Taylor), and the Departments of Preventive Medicine (Drs Sienko, Davis, and Taylor), Pediatrics (Dr Davis), Medicine (Dr Brooks), and Neurology (Dr Brooks), Amyotrophic Lateral Sclerosis Clinical Research Center, University of Wisconsin School of Medicine, Madison.

Footnotes
Accepted for publication July 11, 1989.

Reprint requests to Bureau of Community Health and Prevention, Wisconsin Division of Health, PO Box 309, Madison, WI 53701-0309 (Dr Davis).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Intake of polyunsaturated fatty acids and vitamin E reduces the risk of developing amyotrophic lateral sclerosis
Veldink et al.
J. Neurol. Neurosurg. Psychiatry 2007;78:367-371.
ABSTRACT | FULL TEXT  

Incidence of ALS in Italy: Evidence for a uniform frequency in Western countries
Neurology 2001;56:239-244.
ABSTRACT | FULL TEXT  

Geographical epidemiology of residence of patients with motor neuron disease in Lancashire and south Cumbria
Mitchell et al.
J. Neurol. Neurosurg. Psychiatry 1998;65:842-847.
ABSTRACT | FULL TEXT  

The Epidemiology of Parkinson's Disease: A Case-Control Study of Young-Onset and Old-Onset Patients
Stern et al.
Arch Neurol 1991;48:903-907.
ABSTRACT