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Memory Impairment in Patients With Progressive Supranuclear Palsy
Irene Litvan, MD;
Jordan Grafman, PhD;
Claudia Gomez, MEd;
Thomas N. Chase, MD
Arch Neurol. 1989;46(7):765-767.
Abstract
• Verbal memory was compared in 12 patients with progressive supranuclear palsy and 12 healthy control subjects matched for age, sex, and education. Learning, consolidation, and retrieval were significantly impaired in patients with progressive supranuclear palsy. Information scanning, which requires the use of short-term memory processes, remained intact. Duration of symptoms and degree of motor dysfunction correlated with intrusions during learning. No relation between central dopamine metabolism and memory dysfunction could be established.
Author Affiliations
From the Experimental Therapeutics Branch (Drs Litvan and Chase and Ms Gomez) and the Cognitive Neuroscience Unit, Medical Neurology Branch (Dr Grafman), National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Md.
Footnotes
Accepted for publication November 17, 1988.
Read in part at the 40th annual meeting of the American Academy of Neurology, Cincinnati, Ohio, April 1988.
Reprint requests to Experimental Therapeutics Branch, Bldg 10, Room 5C103, NINDS, National Institutes of Health, Bethesda, MD 20892 (Dr Chase).
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