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Prediction by Cerebrospinal Fluid Enzyme Analysis

Risto O. Roine, MD; Hannu Somer, MD; Markku Kaste, MD; Lasse Viinikka, MD; Sirkka-Liisa Karonen, PhD

Arch Neurol. 1989;46(7):753-756.

Abstract
• The prognostic value of cerebrospinal fluid (CSF) and serum neuron-specific enolase and brain-type creatine kinase isozyme (CK-BB) measurements was studied in 75 consecutive victims of out-of-hospital cardiac arrest. All patients with a CSF neuron-specific enolase level of more than 24 ng/ml 24 hours after cardiac arrest remained unconscious and died. The CSF CK-BB level was as reliable as an index of brain injury.Cerebrospinal fluid neuron-specific enolase, CSF CK-BB and serum neuron-specific enolase levels correlated with the neurological outcome at 3 months. Thus, the analysis of these enzymes in CSF seems to be useful in the early prognostic assessment of cardiac arrest victims.

Author Affiliations
From the Departments of Neurology (Drs Roine, Somer, and Kaste) and Clinical Chemistry (Dr Karonen), and the Laboratory of Children's Hospital (Dr Viinikka), University of Helsinki (Finland).

Footnotes
Accepted for publication November 30, 1988.

Reprint requests to Department of Neurology, University Central Hospital, SF-00290 Helsinki, Finland (Dr Roine).

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