Neurological Outcome After Out-of-Hospital Cardiac Arrest: Prediction by Cerebrospinal Fluid Enzyme Analysis

doi:10.1001/archneur.1989.00520430047015

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Vol. 46 No. 7, July 1989

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Neurological Outcome After Out-of-Hospital Cardiac Arrest

Prediction by Cerebrospinal Fluid Enzyme Analysis

Risto O. Roine, MD; Hannu Somer, MD; Markku Kaste, MD; Lasse Viinikka, MD; Sirkka-Liisa Karonen, PhD

Arch Neurol. 1989;46(7):753-756.

Abstract

• The prognostic value of cerebrospinal fluid (CSF) andserum neuron-specific enolase and brain-type creatine kinaseisozyme (CK-BB) measurements was studied in 75 consecutive victimsof out-of-hospital cardiac arrest. All patients with a CSF neuron-specificenolase level of more than 24 ng/ml 24 hours after cardiac arrestremained unconscious and died. The CSF CK-BB level was as reliableas an index of brain injury.Cerebrospinal fluid neuron-specificenolase, CSF CK-BB and serum neuron-specific enolase levelscorrelated with the neurological outcome at 3 months. Thus,the analysis of these enzymes in CSF seems to be useful in theearly prognostic assessment of cardiac arrest victims.

Author Affiliations

From the Departments of Neurology (Drs Roine, Somer, and Kaste) and Clinical Chemistry (Dr Karonen), and the Laboratory of Children's Hospital (Dr Viinikka), University of Helsinki (Finland).

Footnotes

Accepted for publication November 30, 1988.

Reprint requests to Department of Neurology, University CentralHospital, SF-00290 Helsinki, Finland (Dr Roine).

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