Opsoclonus in organophosphate poisoning
P. Pullicino and J. Aquilina
Department of Medicine, University of Malta, Gwardamangia.
Transient opsoclonus was observed in a patient who attempted suicide with
the organophosphate insecticide Malathion
(diethyl[dimethoxyphosphinothioyl]thiobutanedioate). Several toxins can
cause opsoclonus, and these must be considered in its differential
diagnosis. Eye movement disorders are one of the more common manifestations
of organophosphate intoxication, and opsoclonus should now be included
among these. Acetylcholine may be a neurotransmitter in the ocular motor
pathway.
