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David L. Bushnell, MD; Sudha Gupta, MD; Anthony G. Mlcoch, PhD; W. Earl Barnes, PhD

Arch Neurol. 1989;46(6):665-669.

Abstract
• Fourteen patients (10 with left-sided and 4 with right-sided cerebral infarction) were prospectively studied with single-photon emission computed tomography (SPECT) using N-isopropyl-p-(1 123) iodoamphetamine (IMP, SPECTamine) to determine its usefulness in predicting neurologic/language recovery after cerebral infarction. All neuro-SPECT imaging was performed within 30 days after infarction. Detailed assessment of neurologic and/or language recovery (after 3 months) was carried out prospectively in each patient. Patients with smaller volume IMP defects in the region of infarction demonstrated significantly better neurologic and language recovery than patients with large IMP defects. Analysis of the IMP "redistribution" phenomenon failed to demonstrate definitively a relationship with clinical recovery. It was concluded that the volume of the IMP defect can aid in predicting recovery potential after cerebral infarction.

Author Affiliations
From the Nuclear Medicine (Drs Bushnell and Barnes), Neurology (Dr Gupta), and Audiology and Speech Pathology (Dr Mlcoch) Services, Hines (Ill) Veterans Administration Hospital, the Departments of Neurology (Dr Gupta) and Otorhinolaryngology (Dr Mlcoch), Loyola University Medical School, Maywood, Ill, and the Department of Internal Medicine, Chicago Medical School, North Chicago, Ill (Dr Bushnell).

Footnotes
Accepted for publication December 14, 1988.

Reprint requests to Nuclear Medicine Service, Hines Veterans Administration Hospital, Hines, IL 60141 (Dr Bushnell).

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