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Rachel Pauzner, MD; Meir Mouallem, MD; Menachem Sadeh, MD; Rina Tadmor, MD; Zvi Farfel, MD

Arch Neurol. 1989;46(5):510-512.

Abstract
• An awake patient presented with central neurogenic hyperventilation induced by a cerebral tumor. Corticosteroid therapy and brain irradiation while the patient was anesthetized and respiration controlled under pancuronium-induced respiratory paralysis were followed by tumor regression and resolution of hyperventilation. Recurrence of tumor 6 weeks later was not accompanied by recurrence of hyperventilation. Cytologic study of cerebrospinal fluid revealed B-cell lymphoma. This patient brings to 10 the number of cases recorded with tumor-induced central neurogenic hyperventilation. Five of the eight patients with known tumor histology had a primary cerebral lymphoma, a rare neoplasm that comprises only 1% of all intracranial neoplasms. The disproportionately high frequency of central neurogenic hyperventilation in patients with cerebral lymphoma has therapeutic implications that are briefly reviewed.

Author Affiliations
From the Departments of Medicine E (Drs Pauzner, Mouallem, and Farfel), Neurology (Dr Sadeh), and Neuroradiology (Dr Tadmor), Chaim Sheba Medical Center, Tel Hashomer, Israel, and Sackler School of Medicine, Tel Aviv (Israel) University.

Footnotes
Accepted for publication September 15, 1988.

Reprint requests to Department of Medicine E, Sheba Medical Center, 52621 Tel Hashomer, Israel (Dr Farfel).

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