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Cerebrospinal Fluid Immunoglobulins and Multiple SclerosisCorrespondence With Magnetic Resonance Imaging and Visually Evoked Potential Changes
Felix A. J. Müller, MD;
Paul E. Hänny, MD;
Werner Wichmann, MD;
Walter Fierz, MD;
Max R. Dürsteler, MD
Arch Neurol. 1989;46(4):367-371.
Abstract
• The clinical (disability) and paraclinical (visually evoked potential [VEP]/ magnetic resonance imaging [MRI]) data of patients with definite or probable multiple sclerosis (MS) were compared with their cerebrospinal fluid (CSF) immunoglobulins taken within the same period of time. For patients with definite diagnosis by the Schumacher criteria (n = 61) we found significant correlations between CSF immunoglobulin content (absolute  -globulin value [aggv]) and quantified MRI factors (r =.47), between aggv and the sum of VEP latencies of both eyes (r =.53), and also between MRI and VEP changes (r =.62). This was not true for the patients with a probable MS diagnosis and for patients with first attacks. No correlations were evident between aggv and disability status or duration of the illness. The results give support to recent neuropathologic and experimental findings in animals indicating close pathogenic connections between CSF immunoglobulins and demyelination in MS.
Author Affiliations
From the Department of Neurology (Drs Müller, Hänny, and Dürsteler), Division of Neuroradiology (Dr Wichmann), and the Department of Clinical Immunology (Dr Fierz), University Hospital, Zurich.
Footnotes
Accepted for publication Sept 15, 1988.
Reprint requests to Neurologische Klinik, Universitätsspital, CH-8091 Zurich, Switzerland (Dr Müller).
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