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  Vol. 46 No. 4, April 1989 TABLE OF CONTENTS
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Cerebrospinal fluid immunoglobulins and multiple sclerosis. Correspondence with magnetic resonance imaging and visually evoked potential changes

F. A. Muller, P. E. Hanny, W. Wichmann, W. Fierz and M. R. Dursteler
Department of Neurology, University Hospital, Zurich, Switzerland.

The clinical (disability) and paraclinical (visually evoked potential [VEP]/magnetic resonance imaging [MRI]) data of patients with definite or probable multiple sclerosis (MS) were compared with their cerebrospinal fluid (CSF) immunoglobulins taken within the same period of time. For patients with definite diagnosis by the Schumacher criteria (n = 61) we found significant correlations between CSF immunoglobulin content (absolute gamma-globulin value [aggv]) and quantified MRI factors (r = .47), between aggv and the sum of VEP latencies of both eyes (r = .53), and also between MRI and VEP changes (r = .62). This was not true for the patients with a probable MS diagnosis and for patients with first attacks. No correlations were evident between aggv and disability status or duration of the illness. The results give support to recent neuropathologic and experimental findings in animals indicating close pathogenic connections between CSF immunoglobulins and demyelination in MS.

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

HLA-related subpopulations of MS in Japanese with and without oligoclonal IgG bands
Kikuchi et al.
Neurology 2003;60:647-651.
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