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Jeffrey C. Allard, MD; Fred H. Hochberg, MD; Peter D. Franklin, MD; Anthony P. Carter, MD

Arch Neurol. 1989;46(2):184-187.

Abstract
• Because of a family history of neurologic problems and the documentation of three vascular lesions in one patient, we evaluated 18 members representing three family generations with magnetic resonance imaging. Of these, eight were normal, two had abnormalities probably not related to arteriovenous malformation, one scan was suboptimal, and the remaining eight had evidence of hemorrhagic lesions characteristic of arteriovenous malformation. Four of these patients had multiple lesions, and three patients with lesions had no neurologic symptoms. The findings suggest an autosomal dominant mode of inheritance in this unique case of familial cerebral arteriovenous malformation.

Author Affiliations
From the Department of Radiology, Boston University and Boston City Hospital (Drs Allard, Franklin, and Carter); the Department of Neurology, Harvard Medical School and Massachusetts General Hospital, Boston (Dr Hochberg); and Somerset Diagnostic Imaging Center, Boston (Dr Carter). Dr Allard is now with the Department of Radiology, Mt Sinai Medical Center, Miami Beach, Fla.

Footnotes
Accepted for publication June 2, 1988.

Reprint requests to Somerset Diagnostic Imaging Center, 400 Commonwealth Ave, Boston, MA 02215 (Dr Carter).

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