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  Vol. 46 No. 2, February 1989 TABLE OF CONTENTS
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Central nervous system infections in heart and heart-lung transplant recipients

W. A. Hall, A. J. Martinez, J. S. Dummer, B. P. Griffith, R. L. Hardesty, H. T. Bahnson and L. D. Lunsford
Department of Neurological Surgery, University of Pittsburgh School of Medicine.

Infections, a major cause of morbidity and mortality in immunosuppressed heart and heart-lung transplant recipients, frequently involve the central nervous system and can produce devastating neurologic sequelae. Between 1980 and 1987, a total of 363 heart transplant and 54 heart-lung transplant recipients at the University of Pittsburgh sustained 13 intracranial infections two to 143 weeks after transplantation. Computed tomography demonstrated well-defined Nocardia and Aspergillus abscesses in four patients. Cerebrospinal fluid was normal in all cases studied, including in those patients in whom culture confirmed meningitis. Computed tomography-guided stereotactic surgery was used to diagnose and aspirate two nocardial brain abscesses. The prognosis for patients with central nervous system infections was related to their overall condition at the time of diagnosis. Both patients with nocardial abscesses and one patient with Listeria leptomeningitis survived, but all ten other patients died because of extensive multisystem infectious complications.

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Central Nervous System Infections in Heart Transplant Recipients
van de Beek et al.
Arch Neurol 2007;64:1715-1720.
ABSTRACT | FULL TEXT  

Contrasting the Neurologic Complications of Cardiac Transplantation in Adults and Children
Mayer et al.
J Child Neurol 2002;17:195-199.
ABSTRACT  





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