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Aging and Alzheimer's DiseaseAltered Cortical Serotonergic Binding
D. Larry Sparks, PhD
Arch Neurol. 1989;46(2):138-140.
Abstract
• The binding of tritiated serotonin and tritiated spiperone to crude membrane preparations from human frontal poles was determined in both controls and subjects with Alzheimer's disease (AD). Using the dopamine-specific receptor antagonist sulpiride, spiperone binding in the cortex was shown to be essentially serotonergic. A decline in both serotonin and spiperone binding was found in normal aging, and an AD-related decrease was found for spiperone binding only. The AD-related decrement of spiperone binding occurred irrespective of patient age and duration of disease. Scatchard analysis indicates that both age- and diseaserelated decrements represent a decrease in receptor number.
Author Affiliations
From the Sanders-Brown Research Center on Aging, the Department of Neurology, University of Kentucky Medical Center, and the Kentucky State Medical Examiners Program, Justice Cabinet, Lexington.
Footnotes
Accepted for publication June 8, 1988.
Reprint requests to Department of Neurology, University of Kentucky Medical Center, Lexington, KY 40536-0230 (Dr Sparks).
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