This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

A Positron Emission Tomographic Study

Jack M. Rozental, MD, PhD; Ross L. Levine, MD; Robert J. Nickles, PhD; Jeffrey A. Dobkin, MD

Arch Neurol. 1989;46(12):1302-1307.

Abstract
• Positron emission tomographic scanning with fludeoxyglucose F 18 (¹⁸F-fluorodeoxyglucose) was used to study acute changes in gliomas after chemotherapy. In six experimental subjects, scans were obtained before and at days 1, 7, and 30 after treatment. Five control patients with gliomas who did not undergo chemotherapy had two scans, 1 month apart. Ratios were calculated between peak tumor regional cerebral metabolic rate for glucose and contralateral white matter. The percent change in ratios relative to each patient's baseline scan was calculated. Ratios in three stable controls remained unchanged over the study interval; in two controls it increased 155% and 36% and both died of tumor progression. In experimental subjects, ratios increased 20% to 100% 24 hours after chemotherapy and then decreased until at 28 days they varied between 22% above and 35% below baseline. The increased fludeoxyglucose F 18 uptake at 24 hours could be from uncoupling oxidative phosphorylation or shunting glucose to ribose phosphates for salvage nucleoside synthesis.

Author Affiliations
From the Neurology and Research Services (Drs Rozental and Levine) and the Division of Nuclear Medicine (Dr Dobkin), William S. Middleton Memorial Veterans Administration (VA) Hospital, Madison, Wis; and the Departments of Neurology (Drs Rozental and Levine), Neurosurgery (Dr Rozental), Radiology (Dr Levine), and Medical Physics (Dr Nickles), University of Wisconsin Medical School, Madison.

Footnotes
Accepted for publication May 22, 1989.

Reprint requests to Neurology Service, William S. Middleton Memorial VA Hospital, 2500 Overlook Terr, Madison, WI 53705 (Dr Rozental).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Positron Emission Tomography As an Imaging Biomarker
Weber
JCO 2006;24:3282-3292.
ABSTRACT | FULL TEXT  

Use of PET for Monitoring Cancer Therapy and for Predicting Outcome
Weber
JNM 2005;46:983-995.
ABSTRACT | FULL TEXT  

Applications of positron emission tomography (PET) in neurology
Tai and Piccini
J. Neurol. Neurosurg. Psychiatry 2004;75:669-676.
ABSTRACT | FULL TEXT  

2-[18F]Fluoro-2-deoxyglucose and Glucose Uptake in Malignant Gliomas before and after Radiotherapy: Correlation with Outcome
Spence et al.
Clin. Cancer Res. 2002;8:971-979.
ABSTRACT | FULL TEXT  

Imaging Techniques for Gene Therapy: SPECT, PET, and MRI
Haberkorn and Altmann
Journal of Pharmacy Practice 2001;14:383-396.
ABSTRACT  

Imaging Brain Tumor Proliferative Activity with [124I]Iododeoxyuridine
Blasberg et al.
Cancer Res. 2000;60:624-635.
ABSTRACT | FULL TEXT  

Positron emission tomography and the central nervous system
Robinson et al.
Arch. Dis. Child. 1999;81:263-270.
FULL TEXT  

Effect of Chemotherapy on Glioma Metabolism
Maker
Arch Neurol 1991;48:569-569.
ABSTRACT  

Effect of Chemotherapy on Glioma Metabolism-Reply
Rozental and Levine
Arch Neurol 1991;48:569-570.
ABSTRACT