This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Mary Sano, PhD; Yaakov Stern, PhD; Janet Williams, DSW; Lucien Coté, MD; Ruth Rosenstein, MPh; Richard Mayeux, MD

Arch Neurol. 1989;46(12):1284-1286.

Abstract
• Dementia and depression in patients with Parkinson's disease have been reported separately, but their prevalence is controversial. This study examines the coexistence of these two problems and suggests a common underlying biochemical system. We examined these two entities by retrospective chart review and cerebrospinal fluid biochemistry. We found a prevalence of 10.9% for dementia, 51% for depression, and 5.4% for coincident depression and dementia. In a prospective study of patients with Parkinson's disease we found a continuum of cerebrospinal fluid 5-hydroxyindoleacetic acid concentrations. Patients who were either depressed or demented had lower concentrations of this metabolite than other patients with Parkinson's disease, but patients who were depressed and demented had the lowest levels. These results suggest that the coexistence of dementia and depression represents a unique clinical entity in Parkinson's disease. The serotonergic system may be involved in depression and dementia because evidence of a cumulative effect on this biochemical system is present.

Author Affiliations
From the Departments of Neurology (Drs Sano, Mayeux, Stern, Coté, and Rosenstein) and Psychiatry (Drs Mayeux, Stern, and Williams), College of Physicians and Surgeons, Columbia University, New York, NY.

Footnotes
Accepted for publication May 22, 1989.

Reprints not available.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Depressive Symptoms in Parkinson Disease Correlate With Impaired Global and Specific Cognitive Performance
Fernandez et al.
J Geriatr Psychiatry Neurol 2009;22:223-227.
ABSTRACT  

The scientific and clinical basis for the treatment of Parkinson disease (2009)
Olanow et al.
Neurology 2009;72:S1-S136.
ABSTRACT | FULL TEXT  

Minimizing Disability: An Overview of the Pervasiveness, Clinical Manifestations and Treatment of Depression in Parkinson's Disease
Larsen and Dashtipour
Journal of Pharmacy Practice 2008;21:273-277.
ABSTRACT  

Cognitive impairment in Parkinson's disease
Verbaan et al.
J. Neurol. Neurosurg. Psychiatry 2007;78:1182-1187.
ABSTRACT | FULL TEXT  

Prevalence and Treatment of Depression in Parkinson's Disease
Veazey et al.
J. Neuropsychiatry Clin. Neurosi. 2005;17:310-323.
ABSTRACT | FULL TEXT  

Effects of Depression and Parkinson's Disease on Cognitive Functioning
Norman et al.
J. Neuropsychiatry Clin. Neurosi. 2002;14:31-36.
ABSTRACT | FULL TEXT  

An algorithm (decision tree) for the management of Parkinson's disease (2001):: Treatment
Olanow et al.
Neurology 2001;56:S1-S88.
FULL TEXT  

Depression in Parkinson's Disease: The Impact of Symptom Overlap on Prevalence
Hoogendijk et al.
Psychosomatics 1998;39:416-421.
ABSTRACT | FULL TEXT  

Neuropsychological prediction of dementia in Parkinson's disease
Mahieux et al.
J. Neurol. Neurosurg. Psychiatry 1998;64:178-183.
ABSTRACT | FULL TEXT  

Parkinson's disease and depression: evidence for an alteration of the basal limbic system detected by transcranial sonography
Becker et al.
J. Neurol. Neurosurg. Psychiatry 1997;63:590-595.
ABSTRACT | FULL TEXT  

The Occurrence of Depression in Parkinson's Disease: A Community-Based Study
Tandberg et al.
Arch Neurol 1996;53:175-179.
ABSTRACT  

The Frequency and Associated Risk Factors for Dementia in Patients With Parkinson's Disease
Marder et al.
Arch Neurol 1995;52:695-701.
ABSTRACT  

Tritiated Imipramine Binding: A Peripheral Marker for Serotonin in Parkinson's Disease
Sano et al.
Arch Neurol 1991;48:1052-1054.
ABSTRACT