Neurocysticercosis: Short Course of Treatment With Albendazole

doi:10.1001/archneur.1989.00520470099034

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Vol. 46 No. 11, November 1989

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Neurocysticercosis

Short Course of Treatment With Albendazole

Fernando Alarcón, MD; Luis Escalante, MD; Gonzalo Dueñas, MD; Magalit Montalvo, MD; Marcelo Román, MD

Arch Neurol. 1989;46(11):1231-1236.

Abstract

• Eighteen patients with nonenhancing parenchymal braincysts were treated with albendazole; 9 patients were treatedfor 3 days and 9 patients for 1 month at daily doses of 15 mg/kgof body weight. Three months after starting therapy, resultsshowed that in both groups the treatment was highly effective.Control studies carried out in the same group before the trialdid not show any significant improvement. Five patients werecontrols and were treated only with symptomatic drugs. The totaldiameter of the lesions was reduced from 220.1 mm to 52.1 mm,which signifies a reduction of 76.3% in patients treated fora period of 3 days, and from 278.5 mm to 82.1 mm, which is 70.5%,in patients treated for 30 days. We conclude that albendazoleadministered according to the 3-day therapeutic scheme proposedabove is as highly effective for the treatment of parenchymalbrain cysticercosis as the 30-day scheme.

Author Affiliations

From the Departments of Neurology (Drs Alarcón, Montalvo, and Román) and Neuroradiology (Dr Dueñas), Eugenio Espejo Hospital, and the Immunology Department, National Institute of Hygiene and Tropical Medicine (Dr Escalante), Quito, Ecuador.

Footnotes

Accepted for publication April 20, 1989.

Reprint requests to Department of Neurology, Eugenio EspejoHospital, Casilla 8991, Sucursal 7, Quito, Ecuador (Dr Alarcón).

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