This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Tetsuro Tsukamoto, MD; Hirotaka Yamamoto, PhD; Yuzo Iwasaki, MD; Osamu Yoshie, MD; Hiroshi Terunuma, MD; Hiroyoshi Suzuki, MD

Arch Neurol. 1989;46(11):1225-1229.

Abstract
• We studied serum autoantibodies from six patients with paraneoplastic cerebellar degeneration using rat brains. Immunohistochemically, serum samples from four of six patients with uterine or ovarian tumors showed a similar staining pattern, labeling Purkinje cells and various other neurons distributed throughout the brain and spinal cord. The immunoblot study showed that these serum samples recognized the common 52-kd band. Serum from a patient with duct carcinoma of the breast reacted with the 46-kd band with a similar but weaker immunohistochemical reactivity. Serum from another patient with small-cell carcinoma of the lung in whom paraneoplastic cerebellar degeneration and Eaton-Lambert myasthenic syndrome developed recognized the 40-kd and 38-kd bands with a different immunostaining pattern. Autoantibodies in patients with paraneoplastic cerebellar degeneration are directed to a variety of neuronal antigens that may differ from patient to patient.

Author Affiliations
From the Department of Neurology (Dr Tsukamoto), Fukushima (Japan) Medical College; and the Departments of Neurological Sciences (Drs Yamamoto, Iwasaki, Terunuma, and Suzuki) and Bacteriology (Dr Yoshie), Tohoku University School of Medicine, Sendai, Japan.

Footnotes
Accepted for publication March 13, 1989.

Reprint requests to Department of Neurology, Fukushima Medical College, Hikari-ga-oka 1, Fukushima 960-12, Japan (Dr Tsukamoto).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

A Post-Transcriptional Regulatory Mechanism Restricts Expression of the Paraneoplastic Cerebellar Degeneration Antigen cdr2 to Immune Privileged Tissues
Corradi et al.
J. Neurosci. 1997;17:1406-1415.
ABSTRACT | FULL TEXT  

Ultrastructural Localization of Anti-Purkinje Cell Antibody--Binding Sites in Paraneoplastic Cerebellar Degeneration
Hida et al.
Arch Neurol 1994;51:555-558.
ABSTRACT