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David P. Salmon, PhD; Pow F. Kwo-on-Yuen, MD; William C. Heindel, PhD; Nelson Butters, PhD; Leon J. Thal, MD

Arch Neurol. 1989;46(11):1204-1208.

Abstract
• Patients with dementia of the Alzheimer type (DAT) and Huntington's disease (HD) were assessed with the Dementia Rating Scale, a brief mental status examination that provides a global dementia score and subtest scores for attention, initiation, construction, conceptualization, and memory capacities. Although the patients with DAT and the patients with HD were precisely matched in terms of total Dementia Rating Scale score, different subtest score profiles emerged. Patients with DAT were more impaired than patients with HD on the Memory subtest, whereas patients with HD were more impaired than patients with DAT on the Initiation subtest. These results are indicative of qualitative differences in the cognitive impairment of the two disorders and demonstrate that such differences can be elucidated with brief mental status examinations.

Author Affiliations
From the San Diego (Calif) Veterans Administration Medical Center and the Departments of Psychiatry (Drs Salmon and Butters) and Neurosciences (Drs Kwo-on-Yuen, Heindel, and Thal), University of California School of Medicine at San Diego.

Footnotes
Accepted for publication April 7, 1989.

Presented in part at the 18th annual meeting of the Society for Neuroscience, Toronto, Canada, November 13-18, 1988.

Reprint requests to Riford Clinic (H-204), University of California Medical Center, 225 Dickinson St, San Diego, CA 92103 (Dr Salmon).

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