This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

William W. Beatty, PhD; Donald E. Goodkin, MD; Nancy Monson; Patricia A. Beatty, PhD

Arch Neurol. 1989;46(10):1113-1119.

Abstract
• The performance of 42 patients with relapsing remitting (RR) multiple sclerosis was compared with that of 24 age-, education-, and gender-matched control subjects on a battery of neuropsychological tests known from previous studies to be sensitive to the impairments of patients with chronic progressive (CP) multiple sclerosis. Like CP patients, RR patients exhibited deficits on tests of informationprocessing speed, verbal fluency, and problem solving, and on recall measures of anterograde and remote memory. Although a few patients were mildly dysnomic, the RR patients were not generally impaired on visual confrontation naming and they did not exhibit perseverative responding on verbal fluency measures. The pattern of neuropsychological deficits exhibited by RR patients closely approximates the profile observed in other sub-cortical dementias and does not contain the features of cortical dementia evident in some CP patients. The impairments of RR patients on cognitive tests were less severe than those observed in CP patients in our previous studies. Differences in the age of patients in the CP and RR groups did not account for group differences in the severity of cognitive impairments, but differences in disease duration or severity of disability, as well as disease course, could explain why CP patients exhibit more serious cognitive disturbances than RR patients.

Author Affiliations
From the Clinical Neuroscience Research Program, Neuropsychiatric Research Institute, Fargo, ND (Dr W. W. Beatty and Ms Monson); Department of Psychology, North Dakota State University, Fargo (Drs W. W. Beatty and P. A. Beatty); and Cleveland (Ohio) Clinic Foundation (Dr Goodkin).

Footnotes
Accepted for publication April 24, 1989.

Reprint requests to Department of Psychology, North Dakota State University, Fargo, ND 58105 (Dr W. W. Beatty).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Cognitive impairments in relapsing-remitting multiple sclerosis: a meta-analysis
Prakash et al.
Mult Scler 2008;14:1250-1261.
ABSTRACT  

Cognitive dysfunction in patients with relapsing-remitting multiple sclerosis
Nocentini et al.
Mult Scler 2006;12:77-87.
ABSTRACT  

A longitudinal study of cognition in primary progressive multiple sclerosis
Camp et al.
Brain 2005;128:2891-2898.
ABSTRACT | FULL TEXT  

Fatigue in multiple sclerosis: multidimensional assessment and response to symptomatic treatment
Romani et al.
Mult Scler 2004;10:462-468.
ABSTRACT  

Cognitive strategies application of multiple sclerosis patients
Birnboim and Miller
Mult Scler 2004;10:67-73.
ABSTRACT  

Longitudinal study of cognitive dysfunction in multiple sclerosis: neuropsychological, neuroradiological, and neurophysiological findings
Piras et al.
J. Neurol. Neurosurg. Psychiatry 2003;74:878-885.
ABSTRACT | FULL TEXT  

Screening for multiple sclerosis cognitive impairment using a self-administered 15-item questionnaire
Benedict et al.
Mult Scler 2003;9:95-101.
ABSTRACT  

Fluency in multiple sclerosis: which measure is best?
Beatty
Mult Scler 2002;8:261-264.
ABSTRACT  

The Brief Repeatable Battery of Neuropsychological Tests: normative values allow application in multiple sclerosis clinical practice
Boringa et al.
Mult Scler 2001;7:263-267.
ABSTRACT  

Electroencephalographic coherence analysis in multiple sclerosis: correlation with clinical, neuropsychological, and MRI findings
Leocani et al.
J. Neurol. Neurosurg. Psychiatry 2000;69:192-198.
ABSTRACT | FULL TEXT  

MR Lesion Load and Cognitive Function in Patients with Relapsing-Remitting Multiple Sclerosis
Fulton et al.
Am. J. Neuroradiol. 1999;20:1951-1955.
ABSTRACT | FULL TEXT  

Assessment of cognitive and psychological functions in patients with multiple sclerosis: considerations for databasing
Beatty
Mult Scler 1999;5:239-243.
ABSTRACT  

Neuropsychologic Status in Multiple Sclerosis After Treatment With Glatiramer
Weinstein et al.
Arch Neurol 1999;56:319-324.
ABSTRACT | FULL TEXT  

Cortical lesions in multiple sclerosis
Kidd et al.
Brain 1999;122:17-26.
ABSTRACT | FULL TEXT  

Impairments of attention in individuals with Multiple Sclerosis
Paul et al.
Mult Scler 1998;4:433-439.
ABSTRACT  

Neuropsychological assessment in multiple sclerosis: methodological issues and concerns
Hutchinson et al.
Mult Scler 1996;2:57-65.
ABSTRACT  

Cognitive Impairment in Early-Onset Multiple Sclerosis: Pattern, Predictors, and Impact on Everyday Life in a 4-Year Follow-up
Amato et al.
Arch Neurol 1995;52:168-172.
ABSTRACT  

What Do We Really Know About Cognitive Dysfunction, Affective Disorders, and Stress in Multiple Sclerosis? A Practitioner's Guide
Fischer et al.
Neurorehabil Neural Repair 1994;8:151-164.
ABSTRACT  

Psychoremediation of Communication Skills for Cognitively Impaired Persons with Multiple Sclerosis
Foley et al.
Neurorehabil Neural Repair 1994;8:165-176.
ABSTRACT  

Issues and Developments in the Neuropsychological Assessment of Patients with Multiple Sclerosis
Beatty and Scott
Neurorehabil Neural Repair 1993;7:87-97.
 

Neuropsychological Importance of Subcortical White Matter Hyperintensity
Tupler et al.
Arch Neurol 1992;49:1248-1252.
ABSTRACT  

Automatic Memory Processes in Patients With Multiple Sclerosis
Grafman et al.
Arch Neurol 1991;48:1072-1075.
ABSTRACT  

Remote Memory for Visuospatial Information in Patients with Alzheimer's Disease
Beatty and Salmon
J Geriatr Psychiatry Neurol 1991;4:14-17.
ABSTRACT  

Clinical and Demographic Predictors of Cognitive Performance in Multiple Sclerosis: Do Diagnostic Type, Disease Duration, and Disability Matter?
Beatty et al.
Arch Neurol 1990;47:305-308.
ABSTRACT  

Lexical Processing in Parkinson's Disease and Multiple Sclerosis
Beatty and Monson
J Geriatr Psychiatry Neurol 1989;2:145-152.
ABSTRACT  

Access to Semantic Memory in Parkinson's Disease and Multiple Sclerosis
Beatty et al.
J Geriatr Psychiatry Neurol 1989;2:153-162.
ABSTRACT