Chronic manganese intoxication

C. C. Huang, N. S. Chu, C. S. Lu, J. D. Wang, J. L. Tsai, J. L. Tzeng, E. C. Wolters and D. B. Calne
Department of Neurology, Chang Gung Medical College Hospital, Taipei, Taiwan, Republic of China.

We report six cases of chronic manganese intoxication in workers at a ferromanganese factory in Taiwan. Diagnosis was confirmed by assessing increased manganese concentrations in the blood, scalp, and pubic hair. In addition, increased manganese levels in the environmental air were established. The patients showed a bradykinetic-rigid syndrome indistinguishable from Parkinson's disease that responded to treatment with levodopa.

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

A Preliminary Study Revealing a New Association in Patients Undergoing Maintenance Hemodialysis: Manganism Symptoms and T1 Hyperintense Changes in the Basal Ganglia
da Silva et al.
Am. J. Neuroradiol. 2007;28:1474-1479.
ABSTRACT | FULL TEXT  

Manganese-Induced Neurotoxicity: The Role of Astroglial-Derived Nitric Oxide in Striatal Interneuron Degeneration
Liu et al.
Toxicol Sci 2006;91:521-531.
ABSTRACT | FULL TEXT  

Searching for a relationship between manganese and welding and Parkinson's disease
Jankovic
Neurology 2005;64:2021-2028.
ABSTRACT | FULL TEXT  

Neurologic manifestations in welders with pallidal MRI T1 hyperintensity
Josephs et al.
Neurology 2005;64:2033-2039.
ABSTRACT | FULL TEXT  

The Pathogenesis of Machado Joseph Disease: A High Manganese/Low Magnesium Initiated CAG Expansion Mutation in Susceptible Genotypes?
Purdey
J. Am. Coll. Nutr. 2004;23:715S-729S.
ABSTRACT | FULL TEXT  

Effect of levodopa treatment for parkinsonism in welders: A double-blind study
Koller et al.
Neurology 2004;62:730-733.
ABSTRACT | FULL TEXT  

Chronic Parkinsonism Associated With Cirrhosis: A Distinct Subset of Acquired Hepatocerebral Degeneration
Burkhard et al.
Arch Neurol 2003;60:521-528.
ABSTRACT | FULL TEXT  

Paraparesis, hypermanganesaemia, and polycythaemia: a novel presentation of cirrhosis
Gospe et al.
Arch. Dis. Child. 2000;83:439-442.
ABSTRACT | FULL TEXT  

Diagnosis of Chronic Manganese Intoxication by Magnetic Resonance Imaging
Arjona et al.
NEJM 1997;336:965-965.
FULL TEXT