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Chin-Chang Huang, MD; Nai-Shin Chu, MD; Chin-Song Lu, MD; Jung-Der Wang, MD; Jin-Lian Tsai, MSc; Jia-Liang Tzeng; Erik C. Wolters, MD; Donald B. Calne, MD

Arch Neurol. 1989;46(10):1104-1106.

Abstract
• We report six cases of chronic manganese intoxication in workers at a ferromanganese factory in Taiwan. Diagnosis was confirmed by assessing increased manganese concentrations in the blood, scalp, and pubic hair. In addition, increased manganese levels in the environmental air were established. The patients showed a bradykinetic-rigid syndrome indistinguishable from Parkinson's disease that responded to treatment with levodopa.

Author Affiliations
From the Departments of Neurology, Chang Gung Medical College Hospital (Drs Huang, Chu, and Lu) and National Taiwan University Hospital (Dr Wang), School of Technology, Kaohsiung Medical College (Ms Tsai), and Institute of Nuclear Science, National Tsing-Hua University (Mr Tzeng), Taipei, Taiwan, Republic of China; and the Department of Medicine, Division of Neurology, University of British Columbia, Vancouver (Drs Wolters and Calne).

Footnotes
Accepted for publication December 3, 1988.

Reprint requests to Department of Neurology, Chang Gung Medical College, Chang Gung Memorial Hospital, 199 Tung Hwa North Rd, Taipei 10591, Taiwan, Republic of China (Dr Huang).

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