 |
|
Paradoxical Kinesia in Parkinsonism Is Not Caused by Dopamine ReleaseStudies in an Animal Model
Kristen A. Keefe;
John D. Salamone;
Michael J. Zigmond;
Edward M. Stricker, PhD
Arch Neurol. 1989;46(10):1070-1075.
Abstract
• Rats become akinetic after large dopamine-depleting brain lesions, yet they show an activation-induced restoration of motor function. In this study, rats were given intraventricular injections of the neurotoxin 6-hydroxydopamine to permanently reduce the dopamine content of the corpus striatum by 98%. Although the rats were akinetic in their home cages, they swam effectively when placed in deep water and escaped from a shallow floating ice bath. These behaviors were not abolished by pretreating the animals with the dopamine antagonists haloperidol and SCH-23390. In contrast, haloperidol completely blocked the brain-damaged animals' behavioral responses to amphetamine. These results suggest that the paradoxical kinesia of dopamine-depleted rats is not a consequence of dopamine release from residual dopaminergic fibers.
Author Affiliations
From the Departments of Behavioral Neuroscience and Psychiatry and the Center for Neuroscience, University of Pittsburgh (Pa).
Footnotes
Accepted for publication March 8, 1989.
Reprint requests to Department of Behavioral Neuroscience, University of Pittsburgh, 446 Crawford Hall, Pittsburgh, PA 15260 (Ms Keefe).
 CiteULike  Connotea  Delicious  Digg  Facebook  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Spinal cord stimulation failed to relieve akinesia or restore locomotion in Parkinson disease
Nicolelis et al.
Neurology 2010;75:1484-1485.
FULL TEXT
Predicting falls in Parkinson disease: A step in the right direction
Thevathasan and Aziz
Neurology 2010;75:107-108.
FULL TEXT
Reward Processing in Health and Parkinson's Disease: Neural Organization and Reorganization
Goerendt et al.
Cereb Cortex 2004;14:73-80.
ABSTRACT
| FULL TEXT
Feeding behavior in dopamine-deficient mice
Szczypka et al.
Proc. Natl. Acad. Sci. USA 1999;96:12138-12143.
ABSTRACT
| FULL TEXT
|
