You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.


ABOUT ARCHIVES
Advanced Search

Welcome   | My Account | E-mail Alerts | Access Rights | Sign In


  Vol. 46 No. 1, January 1989 TABLE OF CONTENTS
  Archives
  •  Online Features
  ARTICLE
 This Article
 • Reply to article
 •Send to a friend
 • Save in My Folder
 •Save to citation manager
 •Permissions
 Citing Articles
 •Citation map
 •Citing articles on HighWire
 •Contact me when this article is cited
 Related Content
 •Similar articles in this journal

Striatal dysfunction in attention deficit and hyperkinetic disorder

H. C. Lou, L. Henriksen, P. Bruhn, H. Borner and J. B. Nielsen
Department of Neuropediatrics, J. F. Kennedy Institute, Glostrup, Denmark.

We have previously reported that periventricular structures are hypoperfused in attention deficit and hyperactivity disorder (ADHD). This study has expanded the number of patients, who were divided into two groups: six patients with pure ADHD, and 13 patients with ADHD in combination with other neurologic symptoms. By using xenon 133 inhalation and emission tomography, the regional cerebral blood flow distribution was determined and compared with a control group. Striatal regions were found to be hypoperfused and, by inference, hypofunctional in both groups. This hypoperfusion was statistically significant in the right striatum in ADHD, and in both striatal regions in ADHD with other neuropsychologic and neurologic symptoms. The primary sensory and sensorimotor cortical regions were highly perfused. Methylphenidate increased flow to striatal and posterior periventricular regions, and tended to decrease flow to primary sensory regions. Low striatal activity, partially reversible with methylphenidate, appears to be a cardinal feature in ADHD.

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Co-Occurring Mental and Substance Use Disorders: The Neurobiological Effects of Chronic Stress
Brady and Sinha
Focus 2007;5:229-239.
ABSTRACT | FULL TEXT  

Hemispheric functioning in children with subtypes of attention-deficit/hyperactivity disorder.
Rolfe et al.
J Atten Disord 2006;10:20-27.
ABSTRACT  

What Is Attention-Deficit Hyperactivity Disorder (ADHD)?
Furman
J Child Neurol 2005;20:994-1002.
ABSTRACT  

Co-Occurring Mental and Substance Use Disorders: The Neurobiological Effects of Chronic Stress
Brady and Sinha
Am. J. Psychiatry 2005;162:1483-1493.
ABSTRACT | FULL TEXT  

Abnormal Brain Activation During Inhibition and Error Detection in Medication-Naive Adolescents With ADHD
Rubia et al.
Am. J. Psychiatry 2005;162:1067-1075.
ABSTRACT | FULL TEXT  

The Effects of Methylphenidate on Neural Systems of Attention in Attention Deficit Hyperactivity Disorder
Shafritz et al.
Am. J. Psychiatry 2004;161:1990-1997.
ABSTRACT | FULL TEXT  

Attention-Deficit Hyperactivity Disorder (ADHD)
Voeller
J Child Neurol 2004;19:798-814.
ABSTRACT  

Altered Control of Visual Fixation and Saccadic Eye Movements in Attention-Deficit Hyperactivity Disorder
Munoz et al.
J. Neurophysiol. 2003;90:503-514.
ABSTRACT | FULL TEXT  

Effects of Methylphenidate Discontinuation on Cerebral Blood Flow in Prepubescent Boys with Attention Deficit Hyperactivity Disorder
Langleben et al.
JNM 2002;43:1624-1629.
ABSTRACT | FULL TEXT  

Proceed, with Caution: SPECT Cerebral Blood Flow Studies of Children and Adolescents with Attention Deficit Hyperactivity Disorder
Castellanos
JNM 2002;43:1630-1633.
FULL TEXT  

Neuropsychiatry of the basal ganglia
Ring and Serra-Mestres
J. Neurol. Neurosurg. Psychiatry 2002;72:12-21.
ABSTRACT | FULL TEXT  

Brain Imaging of Attention Deficit/Hyperactivity Disorder
GIEDD et al.
Ann. N. Y. Acad. Sci. 2001;931:33-49.
ABSTRACT | FULL TEXT  

Attention Deficit/Hyperactivity Disorder as a Right Hemisphere Syndrome: Selective Literature Review and Detailed Neuropsychological Case Studies
STEFANATOS and WASSERSTEIN
Ann. N. Y. Acad. Sci. 2001;931:172-195.
ABSTRACT | FULL TEXT  

Comorbidity in Adults with Attention-Deficit/Hyperactivity Disorder
MARKS et al.
Ann. N. Y. Acad. Sci. 2001;931:216-238.
ABSTRACT | FULL TEXT  

Adults ADHD: Concluding Thoughts
WOLF and WASSERSTEIN
Ann. N. Y. Acad. Sci. 2001;931:396-408.
ABSTRACT | FULL TEXT  

The Clinical Role of Computerized EEG in the Evaluation and Treatment of Learning and Attention Disorders in Children and Adolescents
Chabot et al.
J. Neuropsychiatry Clin. Neurosi. 2001;13:171-186.
ABSTRACT | FULL TEXT  

Quantitative Morphology of the Corpus Callosum in Children With Neurofibromatosis and Attention-Deficit Hyperactivity Disorder
Kayl et al.
J Child Neurol 2000;15:90-96.
ABSTRACT  

Hypofrontality in Attention Deficit Hyperactivity Disorder During Higher-Order Motor Control: A Study With Functional MRI
Rubia et al.
Am. J. Psychiatry 1999;156:891-896.
ABSTRACT | FULL TEXT  

Topical Review: Functional Brain Imaging in Neuropsychiatric Disorders of Childhood
O'Tuama et al.
J Child Neurol 1999;14:207-221.
ABSTRACT  

Effects of stimulant medication on the lateralisation of line bisection judgements of children with attention deficit hyperactivity disorder
Sheppard et al.
J. Neurol. Neurosurg. Psychiatry 1999;66:57-63.
ABSTRACT | FULL TEXT  

Selective effects of methylphenidate in attention deficit hyperactivity disorder: A functional magnetic resonance study
Vaidya et al.
Proc. Natl. Acad. Sci. USA 1998;95:14494-14499.
ABSTRACT | FULL TEXT  

DOPA Decarboxylase Activity in Attention Deficit Hyperactivity Disorder Adults. A [Fluorine-18]Fluorodopa Positron Emission Tomographic Study
Ernst et al.
J. Neurosci. 1998;18:5901-5907.
ABSTRACT | FULL TEXT  

Diagnosis and Treatment of Attention-Deficit/Hyperactivity Disorder in Children and Adolescents
Goldman et al.
JAMA 1998;279:1100-1107.
ABSTRACT | FULL TEXT  

Is ADHD a disease?
Conners
J Atten Disord 1997;2:3-17.
 

ERP changes induced by methylphenidate in boys with Attention Deficit Hyperactivity Disorder
Miller et al.
J Atten Disord 1996;1:95-113.
ABSTRACT  

Late psychological consequences of cerebrospinal meningitis in children 5-13 years old
Lis
Childhood 1994;2:164-170.
ABSTRACT  

Toward a Neurobiologic Nosology of Attention Deficit Hyperactivity Disorder
Voeller
J Child Neurol 1991;6:S2-S8.
 

Attention Deficit Disorder Without Hyperactivity: A Distinct Behavioral and Neurocognitive Syndrome
Hynd et al.
J Child Neurol 1991;6:S37-S43.
ABSTRACT  

Clinical Management of Attention Deficit Hyperactivity Disorder
Voeller
J Child Neurol 1991;6:S51-S67.
ABSTRACT  

A Possible Pathophysiologic Substrate of Attention Deficit Hyperactivity Disorder
Heilman et al.
J Child Neurol 1991;6:S76-S81.
ABSTRACT  





HOME | CURRENT ISSUE | PAST ISSUES | TOPIC COLLECTIONS | CME | SUBMIT | SUBSCRIBE | HELP
CONDITIONS OF USE | PRIVACY POLICY | CONTACT US | SITE MAP
 
© 1989 American Medical Association. All Rights Reserved.