You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.


Advertisement

ABOUT ARCHIVES
Advanced Search

Welcome   | My Account | E-mail Alerts | RSS | Access Rights | Sign In


  Vol. 46 No. 1, January 1989 TABLE OF CONTENTS
  Online Only
 •  Online First Table of
Contents
  ORIGINAL CONTRIBUTIONS
 •Online Features
 This Article
 •References
 •Full text PDF
 • Reply to article
 •Send to a friend
 • Save in My Folder
 •Save to citation manager
 •Permissions
 Citing Articles
 •Citation map
 •Citing articles on HighWire
 •Citing articles on Web of Science (139)
 •Contact me when this article is cited
 Related Content
 •Similar articles in this journal
 Social Bookmarking
  Add to CiteULike Add to Connotea Add to Delicious Add to Digg Add to Facebook Add to Reddit Add to Technorati Add to Twitter What's this?

Neuropsychological Test Findings in Subjects With Leukoaraiosis

Stephen M. Rao, PhD; Wiley Mittenberg, PhD; Linda Bernardin; Victor Haughton, MD; Gary J. Leo, DO

Arch Neurol. 1989;46(1):40-44.


Abstract



• Focal periventricular white-matter changes (leukoaraiosis) have been identified incidentally on brain imaging in normal healthy individuals and more commonly in the elderly and in hypertensive individuals. It has been suggested that leukoaraiosis represents the early stages of Binswanger's leukoencephalopathy, a dementing process thought to be related to hypertensive cerebrovascular disease. To test this hypothesis, extensive neuropsychological tests were administered to 50 consecutive normotensive, middleaged, healthy volunteers. Ten subjects (20%) had white-matter changes on magnetic resonance scans; 40 subjects (80%) had normal scans. The differences observed on neuropsychological testing between subjects with and without leukoaraiosis were not significant. While this study argues against a link between leukoaraiosis and dementia, prospective longitudinal studies are needed to determine the value of leukoaraiosis in predicting future cognitive decline.



Author Affiliations



From the Departments of Neurology (Drs Rao, Mittenberg, and Leo and Ms Bernardin) and Radiology (Dr Haughton), Medical College of Wisconsin, Milwaukee.


Footnotes



Accepted for publication July 6, 1988.

Reprint requests to Section of Neuropsychology, Medical College of Wisconsin, 1000 N 92nd St, Milwaukee, WI 53226 (Dr Rao).



Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Delicious Delicious   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Multiple sclerosis and cannabis: A cognitive and psychiatric study
Ghaffar and Feinstein
Neurology 2008;71:164-169.
ABSTRACT | FULL TEXT  

Biomarkers of cerebrovascular disease in dementia
MILLS et al.
Br. J. Radiol. 2007;80:S128-S145.
ABSTRACT | FULL TEXT  

Hyperintensities of the Optic Radiation on T2-Weighted MR Images of Elderly Subjects
Kitajima et al.
Am. J. Neuroradiol. 1999;20:1009-1014.
ABSTRACT | FULL TEXT  

Silent Cerebral Infarcts in Sickle Cell Anemia: A Risk Factor Analysis
Kinney et al.
Pediatrics 1999;103:640-645.
ABSTRACT | FULL TEXT  

Eosinophilia-myalgia syndrome: selective cognitive impairment, longitudinal effects, and neuroimaging findings
Armstrong et al.
J. Neurol. Neurosurg. Psychiatry 1997;63:633-641.
ABSTRACT | FULL TEXT  

Association of Dementia Severity With Cortical Gray Matter and Abnormal White Matter Volumes in Dementia of the Alzheimer Type
Stout et al.
Arch Neurol 1996;53:742-749.
ABSTRACT  

Neuropsychological, Psychiatric, and Cerebral Blood Flow Findings in Vascular Dementia and Alzheimer's Disease
Starkstein et al.
Stroke 1996;27:408-414.
ABSTRACT | FULL TEXT  

White Matter Lesions and Disequilibrium in Older People: I. Case-Control Comparison
Baloh et al.
Arch Neurol 1995;52:970-974.
ABSTRACT  

Differences Between Treated and Untreated Hypertensive Subjects in the Extent of Periventricular Hyperintensities Observed on Brain MRI
Fukuda and Kitani
Stroke 1995;26:1593-1597.
ABSTRACT | FULL TEXT  

The Significance of Cerebral White Matter Abnormalities 100 Years After Binswanger's Report : A Review
Pantoni and Garcia
Stroke 1995;26:1293-1301.
ABSTRACT | FULL TEXT  

Are Multiple Cerebral Infarcts Synergistic?
Wolfe et al.
Arch Neurol 1994;51:211-215.
ABSTRACT  

White Matter Changes in Healthy Elderly Persons Correlate With Attention and Speed of Mental Processing
Ylikoski et al.
Arch Neurol 1993;50:818-824.
ABSTRACT  

Neuropsychological Importance of Subcortical White Matter Hyperintensity
Tupler et al.
Arch Neurol 1992;49:1248-1252.
ABSTRACT  

Magnetic Resonance Imaging Signal Hyperintensities in the Deep and Subcortical White Matter: A Comparative Study Between Stroke Patients and Normal Volunteers
Schmidt et al.
Arch Neurol 1992;49:825-827.
ABSTRACT  

White-Matter Hyperintensity and Neuropsychological Functions in Dementia and Healthy Aging
Almkvist et al.
Arch Neurol 1992;49:626-632.
ABSTRACT  

Neuropsychological Correlates of White-Matter Lesions in Healthy Elderly Subjects: A Threshold Effect
Boone et al.
Arch Neurol 1992;49:549-554.
ABSTRACT  

Hypertension and the Brain
Phillips and Whisnant
Arch Intern Med 1992;152:938-945.
ABSTRACT  

Clinical Correlates of White-Matter Changes on Magnetic Resonance Imaging Scans of the Brain
Mirsen et al.
Arch Neurol 1991;48:1015-1021.
ABSTRACT  

A Translation of Otto Binswanger's Article, 'The Delineation of the Generalized Progressive Paralyses'
Blass et al.
Arch Neurol 1991;48:961-972.
ABSTRACT  

Magnetic Resonance Imaging White Matter Lesions and Cognitive Impairment in Hypertensive Individuals
Schmidt et al.
Arch Neurol 1991;48:417-420.
ABSTRACT  

Hereditary Cerebral Hemorrhage With Amyloidosis-Dutch Type: Clinical and Computed Tomographic Analysis of 24 Cases
Haan et al.
Arch Neurol 1990;47:649-653.
ABSTRACT  

Periventricular and White Matter Magnetic Resonance Imaging Hyperintensities Do Not Differ Between Alzheimer's Disease and Normal Aging
Leys et al.
Arch Neurol 1990;47:524-527.
ABSTRACT  

Frontal Systems Impairment Following Multiple Lacunar Infarcts
Wolfe et al.
Arch Neurol 1990;47:129-132.
ABSTRACT  

Leuko-Araiosis on Magnetic Resonance Imaging and Speed of Mental Processing
Junque et al.
Arch Neurol 1990;47:151-156.
ABSTRACT  

Binswanger's Disease: Some Neuropsychological Considerations
Libon et al.
J Geriatr Psychiatry Neurol 1990;3:31-40.
ABSTRACT  

Brain White-Matter Changes in the Elderly Prone to Falling
Masdeu et al.
Arch Neurol 1989;46:1292-1296.
ABSTRACT  





HOME | CURRENT ISSUE | PAST ISSUES | TOPIC COLLECTIONS | CME | PHYSICIAN JOBS | SUBMIT | SUBSCRIBE | HELP
CONDITIONS OF USE | PRIVACY POLICY | CONTACT US | SITE MAP
 
© 1989 American Medical Association. All Rights Reserved.