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  Vol. 46 No. 1, January 1989 TABLE OF CONTENTS
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Characterization of HTLV-I in a T-Cell Line Established From a Patient With Myelopathy

Tatsufumi Nakamura, MD; Mitsuhiro Tsujihata, MD; Susumu Shirabe, MD; Hidenori Matsuo, MD; Yukitaka Ueki, MD; Shigenobu Nagataki, MD

Arch Neurol. 1989;46(1):35-37.


Abstract

• We have established an interleukin 2-dependent, OKT4-positive T-cell line, named HCT-1, from cells in the cerebrospinal fluid obtained from a patient with human T-cell lymphotropic virus type I (HTLV-1)-associated myelopathy. Antigens for HTLV-I were detected in HCT-1 cells by indirect immunofluorescence and Western blot testing, and type C virus particles were detected by electron microscopy. Southern blot analysis of HCT-1 cellular DNA, using an HTLV-I probe, revealed that the integrated provirus genome could not be distinguished from the HTLV-I genome in adult patients with T-cell leukemia.



Author Affiliations

From the First Department of Internal Medicine, Nagasaki (Japan) University School of Medicine (Drs Nakamura, Shirabe, Matsuo, Ueki, and Nagataki), and the School of Allied Medical Sciences, Nagasaki University (Dr Tsujihata).


Footnotes

Accepted for publication Aug 3, 1988.

Reprint requests to First Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki 852, Japan (Dr Nakamura).



Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Chronic Myelopathy Associated with Human T-Lymphotropic Virus Type I (HTLV-I)
Gessain and Gout
ANN INTERN MED 1992;117:933-946.
ABSTRACT  

Increased Adherence of T Cells to Human Endothelial Cells in Patients With Human T-Cell Lymphotropic Virus Type I-Associated Myelopathy
Ichinose et al.
Arch Neurol 1992;49:74-76.
ABSTRACT  

Retrovirus From Human T-Cell Leukemia Virus Type I-Associated Myelopathy Is the Same Strain as a Prototype Human T-Cell Leukemia Virus Type I
Shirabe et al.
Arch Neurol 1990;47:1258-1260.
ABSTRACT  





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