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E. Jeffrey Metter, MD; Daniel Kempler, PhD; Catherine Jackson, MA; Wayne R. Hanson, PhD; John C. Mazziotta, MD, PhD; Michael E. Phelps, PhD

Arch Neurol. 1989;46(1):27-34.

Abstract
• Cerebral glucose metabolism was evaluated in patients with either Wernicke's (N = 7), Broca's (N = 11), or conduction (N = 10) aphasia using¹⁸F-2-fluoro-2-deoxy-D-glucose with positron emission tomography. The three aphasic syndromes differed in the degree of left-to-right frontal metabolic asymmetry, with Broca's aphasia showing severe asymmetry and Wernicke's aphasia mild-to-moderate metabolic asymmetry, while patients with conduction aphasia were metabolically symmetric. On the other hand, the three syndromes showed the same degree of metabolic decline in the left temporal region. The parietal region appeared to separate conduction aphasia from both Broca's and Wernicke's aphasias. Common aphasic features in the three syndromes appear to be due to common changes in the temporal region, while unique features were associated with frontal and parietal metabolic differences.

Author Affiliations
From the Veterans Administration Medical Center, Sepulveda, Calif (Drs Metter, Kempler, and Hanson) and UCLA School of Medicine (Drs Metter, Kempler, Mazziotta, and Phelps and Ms Jackson). Dr Metter is now with the National Institute of Aging, Gerontology Research Center, Baltimore, and Dr Kempler is now with the University of Southern California, Los Angeles, Ethel Percy Andrus Gerontology Center.

Footnotes
Accepted for publication July 22, 1988.

Reprint requests to Gerontology Research Center, 4940 Eastern Ave, Baltimore, MD 21224 (Dr Metter).

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