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Ann Pakalnis, MD; M. E. Drake, Jr, MD; Richard J. Barohn, MD; Donald W. Chakeres, MD; Jerry R. Mendell, MD

Arch Neurol. 1988;45(9):1014-1016.

Abstract
• Eighteen patients with chronic inflammatory demyelinating polyneuropathy were studied with evoked potentials to assess for evidence of central nervous system demyelination. Both visual and brain-stem auditory evoked responses were obtained, and the results were compared with magnetic resonance imaging (MRI). An evoked potential was abnormal in nine of 18 patients, five of whom had central nervous system evidence of demyelination by MRI. Evoked potentials identified four patients with probable anterior optic pathway involvement that was not demonstrable by MRI. These findings continue to support that chronic inflammatory demyelinating polyneuropathy is associated with a central demyelinating disorder and more importantly emphasize the possibility of a common pathogenic mechanism in central and peripheral nerve demyelination.

Author Affiliations
From the Departments of Neurology (Drs Pakalnis, Drake, Barohn, and Mendell) and Radiology (Dr Chakeres), Ohio State University Hospitals, Columbus.

Footnotes
Accepted for publication Feb 29, 1988.

Reprint requests to 430 Means Hall, 1654 Upham Dr, Columbus, OH 43210 (Dr Pakalnis).

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