This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Kwan-Fu Rex Sheu, PhD; Donald D. Clarke, PhD; Young-Tai Kim, PhD; John P. Blass, MD, PhD; Bradford J. Harding; Joseph DeCicco

Arch Neurol. 1988;45(8):841-845.

Abstract
• The partially purified transketolase from each of eight well-nourished patients with Alzheimer's disease contained significantly less heat-stable component with a significantly longer half-life of heat inactivation than that from eight controls. Immunochemical studies utilizing antibodies to the purified human liver transketolase did not distinguish between red blood cell transketolases of patients with Alzheimer's disease and those of controls. However, three brains from patients with Alzheimer's disease that were deficient in transketolase activity lacked a 69-kilodalton form on immunoblots. Subtle structural abnormalities of transketolase appear to occur in a high proportion of patients with Alzheimer's disease.

Author Affiliations
From the Departments of Neurology (Drs Sheu, Clarke, and Blass and Mr Harding and Mr DeCicco) and Medicine (Drs Kim and Blass), Cornell University Medical College, New York, and the Dementia Research Service, Burke Rehabilitation Center, White Plains, NY (Drs Sheu, Clarke, and Blass and Mr Harding and Mr DeCicco). Dr Clarke is currently with the Department of Chemistry, Fordham University, Bronx, NY.

Footnotes
Accepted for publication Feb 15, 1988.

Reprint requests to the Dementia Research Service, Burke Rehabilitation Center, 785 Mamaroneck Ave, White Plains, NY 10605 (Dr Sheu).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Transketolase Is a Major Protein in the Mouse Cornea
Sax et al.
J. Biol. Chem. 1996;271:33568-33574.
ABSTRACT | FULL TEXT  

Amplification of the Transketolase Gene in Desensitization-resistant Mutant Y1 Mouse Adrenocortical Tumor Cells
Schimmer et al.
J. Biol. Chem. 1996;271:4993-4998.
ABSTRACT | FULL TEXT  

Plasma and Red Blood Cell Thiamine Deficiency in Patients With Dementia of the Alzheimer's Type
Gold et al.
Arch Neurol 1995;52:1081-1086.
ABSTRACT  

Preliminary Findings of High-Dose Thiamine in Dementia of Alzheimer's Type
Meador et al.
J Geriatr Psychiatry Neurol 1993;6:222-229.
ABSTRACT  

A Trial of Thiamine in Alzheimer's Disease
Nolan et al.
Arch Neurol 1991;48:81-83.
ABSTRACT  

Relationship of Normal Serum Vitamin B12 and Folate Levels to Cognitive Test Performance in Subtypes of Geriatric Major Depression
Bell et al.
J Geriatr Psychiatry Neurol 1990;3:98-105.
ABSTRACT  

Thiamine and Alzheimer's Disease: A Pilot Study
Blass et al.
Arch Neurol 1988;45:833-835.
ABSTRACT