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Peter J. Whitehouse, MD, PhD; Andrea M. Martino; Kendall A. Marcus; Richard M. Zweig, MD; Harvey S. Singer, MD; Donald L. Price, MD; Kenneth J. Kellar, PhD

Arch Neurol. 1988;45(7):722-724.

Abstract
• Alzheimer's disease, Parkinson's disease, and progressive supranuclear palsy are all characterized by loss of neurons in the basal forebrain cholinergic system and by associated reductions in cortical presynaptic cholinergic markers, such as choline acetyltransferase. In this report, we identify that a major cortical receptor alteration in these disorders is a reduction in nicotinic receptors measured using both tritiated acetylcholine and levorotatory tritiated nicotine binding.

Author Affiliations
From the Neuropathology Laboratory (Drs Whitehouse, Zweig, and Price and Ms Marcus), the Departments of Neurology (Drs Whitehouse, Singer, and Price), Neuroscience (Drs Whitehouse and Price), Pathology (Drs Zweig and Price), and Pediatrics (Dr Singer), The Johns Hopkins University School of Medicine, Baltimore; Department of Pharmacology (Dr Kellar and Ms Martino), Georgetown University School of Medicine and Dentistry, Washington, DC; and Alzheimer Center, University Hospitals of Cleveland (Dr Whitehouse).

Footnotes
Accepted for publication March 21, 1988.

Reprint requests to Alzheimer Center, University Hospitals of Cleveland, Cleveland, OH 44106 (Dr Whitehouse).

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