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One-Year Follow-up of Infants With Abstinence-Associated Seizures
Tatiana M. Doberczak, MD;
Stefan Shanzer, MD;
Rhoda Cutler, PhD;
Ruby T. Senie, PhD;
Joanna A. Loucopoulos, MD;
Stephen R. Kandall, MD
Arch Neurol. 1988;45(6):649-653.
Abstract
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• Fourteen infants with neonatal abstinence-associated seizures were assessed neurodevelopmentally during the first year of life. Despite abnormal neurologic examination results in eight of 12 infants at 2 to 4 months of age, nine of 12 infants had normal neurologic examination results at follow-up (two infants were unavailable for follow-up; one infant died of acquired immunodeficiency syndrome). Nine neonatal electroencephalograms were abnormal; seven of eight of these abnormal tracings normalized during the follow-up period. Bayley developmental scores remained normal during the first year of life and did not differ from either passively addicted infants without seizures or from published population norms. This short-term favorable prognosis for abstinence-associated seizures differs from that associated with neonatal seizures due to other causes. This observed improvement in neurologic function may be based on replenishment of neurotransmitters following transient depletion in the neonatal period.
Author Affiliations
From the Departments of Pediatrics (Drs Doberczak, Loucopoulos, and Kandall), Neurology (Dr Shanzer), Psychiatry (Dr Cutler), and Community Medicine (Dr Senie), Beth Israel Medical Center, Mount Sinai School of Medicine, New York.
Footnotes
Accepted for publication Feb 8, 1988.
Presented in part at the Greater New York Conference on Perinatal Research, New York, Nov 21, 1986.
Reprint requests to Division of Neonatology, Beth Israel Medical Center, First Avenue at 16th Street, New York, NY 10003 (Dr Kandall).
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