 |
|
Antigenic Assessment of Coronaviruses Isolated From Patients With Multiple Sclerosis
John O. Fleming, MD;
Fouad A. K. El Zaatari, PhD;
Wendy Gilmore, PhD;
John D. Berne, MS;
Jack S. Burks, MD;
Stephen A. Stohlman, PhD;
Wallace W. Tourtellotte, MD, PhD;
Leslie P. Weiner, MD
Arch Neurol. 1988;45(6):629-633.
Abstract
• Many studies have either supported or discounted the role of coronaviruses as etiologic agents in multiple sclerosis (MS). Two new approaches were applied to investigate this controversy. First, monoclonal antibodies specific for either murine coronaviruses (mouse hepatitis viruses) or human coronaviruses were used to characterize the antigenic features of MS-derived coronaviruses SK and SD. Both isolates were found to have a mouse hepatitis virus-type profile. Second, serum and cerebrospinal fluid antibodies to different coronaviruses, including SD, were measured in MS and control groups. No significant difference in antibody level to coronaviruses was found between MS and control samples. The results of these antigenic studies do not support a specific association between MS and coronaviruses.
Author Affiliations
From the Department of Neurology, School of Medicine, University of Southern California, Los Angeles (Drs Fleming, El Zaatari, Gilmore, Stohlman, and Weiner and Mr Berne); Department of Neurology, University of Colorado, Denver (Dr Burks); and Department of Neurology, School of Medicine, UCLA (Dr Tourtellotte).
Footnotes
Accepted for publication Dec 11, 1987.
Reprint requests to Department of Neurology, 142 MCH, University of Southern California School of Medicine, 2025 Zonal Ave, Los Angeles, CA 90033 (Dr Fleming).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Proliferative growth of SARS coronavirus in Vero E6 cells
Ng et al.
J. Gen. Virol. 2003;84:3291-3303.
ABSTRACT
| FULL TEXT
|
