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Neuropsychological Impairment in Wilson's Disease
Alice Medalia, PhD;
Kathryn Isaacs-Glaberman, PhD;
I. Herbert Scheinberg, MD
Arch Neurol. 1988;45(5):502-504.
Abstract
• To examine the neuropsychological deficits of patients with Wilson's disease (WD), 19 neurologically impaired patients with WD were administered the Wechsler Adult Intelligence Scale (revised), Wechsler Memory Scale, Dementia Rating Scale, Wisconsin Card Sorting Test, Boston Naming Test, Trail Making Test, and Animal Naming Test. Their test scores were compared with those of 12 neurologically asymptomatic patients with WD and 15 normal controls. The neurologically impaired patients scored lower than did the control group on the Performance IQ, Full-Scale IQ, Dementia Rating Scale, and Trail Making Test, and they scored lower on the Wechsler Memory Scale than did both the asymptomatic and control groups. The major areas of deficit for the neurologically impaired WD group were in motor and memory functioning. Computed tomographic and neurologic examinations of the neurologically impaired patients with WD generally reflected abnormalities of the basal ganglia.
Author Affiliations
From the Department of Psychiatry (Drs Medalia and Isaacs-Glaberman) and the Division of Genetic Medicine, Department of Medicine (Dr Scheinberg), Albert Einstein College of Medicine, Montefiore Hospital Medical Center, Bronx Municipal Hospital Center, New York.
Footnotes
Accepted for publication Dec 15, 1987.
Reprint requests to Bronx Municipal Hospital Center, Psychiatry Room 1009, Eastchester Road and Pelham Parkway South, Bronx, NY 10461 (Dr Medalia).
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