HIPDM-SPECT in patients with medically intractable complex partial seizures. Ictal study
B. I. Lee, O. N. Markand, H. N. Wellman, A. R. Siddiqui, H. M. Park, B. Mock, R. M. Worth, M. K. Edwards and J. Krepshaw
Department of Neurology, Indiana University Medical Center, Indianapolis 46223.
Both interictal and ictal
N,N,N'-trimethyl-N'-(2-hydroxy-3-methyl-5-iodobenzyl)-1,3,propanediamine
-single photon emission computed tomography (HIPDM-SPECT) were performed in
16 patients with medically intractable complex partial seizures. Ictal
HIPDM-SPECT localized epileptic foci in 13 of 14 patients with unilateral
temporal focus and provided confirmative evidence of epileptic focus in 11
patients by demonstrating maximally increased regional cerebral perfusion
(rCP) in epileptic foci that had shown decreased rCP in a previous
interictal study. Ictal HIPDM-SPECT in two patients with bitemporal foci
showed more complicated patterns consisting of slightly increased rCP in
bilateral multifocal regions. Ictal HIPDM-SPECT was particularly useful for
investigating epileptic foci, and correlation with simultaneously recorded
ictal electroencephalograms provided further insight for localizing
epileptic foci.
