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Ictal Study

B. I. Lee, MD; O. N. Markand, MD; H. N. Wellman, MD; A. R. Siddiqui, MD; H. M. Park, MD; B. Mock, PhD; R. M. Worth, MD, PhD; M. K. Edwards, MD; J. Krepshaw, CNMT

Arch Neurol. 1988;45(4):397-402.

Abstract
• Both interictal and ictal N,N,N,'-trimethyl-N'-(2-hydroxy-3-methyl-5-iodobenzyl)-1,3,propanediamine—single photon emission computed tomography (HIPDM-SPECT) were performed in 16 patients with medically intractable complex partial seizures. lctal HIPDM-SPECT localized epileptic foci in 13 of 14 patients with unilateral temporal focus and provided confirmative evidence of epileptic focus in 11 patients by demonstrating maximally increased regional cerebral perfusion (rCP) in epileptic foci that had shown decreased rCP in a previous interictal study. lctal HIPDM-SPECT in two patients with bitemporal foci showed more complicated patterns consisting of slightly increased rCP in bilateral multifocal regions. lctal HIPDM-SPECT was particularly useful for investigating epileptic foci, and correlation with simultaneously recorded ictal electroencephalograms provided further insight for localizing epileptic foci.

Author Affiliations
From the Departments of Neurology (Drs Lee and Markand) and Neurosurgery (Dr Worth), and the Sections of Nuclear Medicine (Drs Wellman, Siddiqui, Park, and Mock, and Mr Krepshaw) and Neuroradiology (Dr Edwards), Indiana University Medical Center, Indianapolis.

Footnotes
Accepted for publication Oct 23, 1987.

Read in part before the 40th annual meeting of the American Epilepsy Society, Seattle, Nov 18, 1986.

Reprint requests to Department of Neurology, Indiana University Medical Center, 702 Barnhill Dr, Indianapolis, IN 46223 (Dr Lee).

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