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Single Photon Emission Computed Tomography in Alzheimer's DiseaseAbnormal Iofetamine I 123 Uptake Reflects Dementia Severity
Keith A. Johnson, MD;
B. Leonard Holman, MD;
Stephen P. Mueller, MD;
T. John Rosen, PhD;
Robert English, CNMT;
J. Steven Nagel, MD;
John H. Growdon, MD
Arch Neurol. 1988;45(4):392-396.
Abstract
• To determine whether abnormalities in regional cerebral functional activity estimated by iofetamine hydrochloride I 123 and single photon emission computed tomography can be detected in mild or moderate as well as severe cases of Alzheimer's disease (AD), we performed iofetamine I 123-single photon emission computed tomography in 37 patients with probable AD (nine patients with mild, 18 patients with moderate, and ten patients with severe dementia) and nine age-matched control subjects. lofetamine I 123 uptake was measured in right and left frontal, temporal, parietal, and occipital cortices. Mean (right and left) iofetamine I 123 activity was lowest in the parietal region of patients with AD and was significantly reduced in the other three regions compared with control subjects. Only in the parietal region was lower relative iofetamine I 123 activity associated with an impaired level of patient function and with cognitive deficit.
Author Affiliations
From the Department of Neurology, Massachusetts General Hospital and Harvard Medical School (Drs Johnson and Growdon), the Department of Radiology, Brigham and Women's Hospital and Harvard Medical School (Drs Holman, Mueller, and Nagel and Mr English), Boston; and the Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge (Dr Rosen).
Footnotes
Accepted for publication Jan 11, 1988.
Reprint requests to Department of Neurology, NMR Facility, Massachusetts General Hospital, Fruit Street, Boston, MA 02114 (Dr Johnson).
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