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Jan C. Den Heijer, MD; Ward L. E. M. Bollen, MD, PhD; Jos P. H. Reulen, PhD; J. Gert van Dijk, MD; Cor G. S. Kramer; Raymund A. C. Roos, MD, PhD; Onno J. S. Buruma, MD, PhD

Arch Neurol. 1988;45(3):309-312.

Abstract
• Autonomic nervous system function was studied by means of a series of standardized tests in 11 patients with Huntington's disease (HD) and in 11 ageand sex-matched controls. Two statistically significant differences were found. The blood pressure response to sustained handgrip was diminished and the pupillary light reflex latency was increased in the HD group. The former probably reflects diminished input from higher centers on an otherwise intact sympathetic nervous system. The latter may indicate involvement of the pretectal or Edinger-Westphal nuclei in HD. No further signs of autonomic nervous system dysfunction were found.

Author Affiliations
From the Departments of Neurology (Drs Den Heijer, Bollen, Roos, and Buruma) and Neurophysiology (Drs Den Heijer and van Dijk and Mr Kramer), University Hospital Leiden (the Netherlands); and Department of Medical Physics, Free University, Amsterdam (Dr Reulen). Dr Den Heijer is now with St Barbara-Hospital Gladbeck (West Germany).

Footnotes
Accepted for publication Oct 6, 1987.

Reprint requests to Department of Neurology, St Barbara-Hospital Gladbeck, PO Box 546, 4390 Gladbeck, West Germany (Dr Den Heijer).

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