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Irene Litvan, MD; Jordan Grafman, PhD; Pere Vendrell, PhD; José M. Martinez, MD

Arch Neurol. 1988;45(3):281-285.

Abstract
• Sixteen patients with a definitive diagnosis of multiple sclerosis (MS) and an equal number of matched controls were administered tests of memory and information processing speed. Results indicated a significant long-term verbal memory impairment in patients with MS, with spared short-term memory and memory scanning. Speed of information processing was evaluated with the Paced Auditory Serial Addition Test. The results for the two highest rates of presentation revealed significantly impaired processing in the MS group. Performance at the higher rates and retrieval of information from long-term memory were significantly correlated. These results suggest that slowed information processing is a deficit that contributes to long-term memory impairment in patients with MS.

Author Affiliations
From the Experimental Therapeutics (Dr Litvan) and Medical Neurology (Dr Grafman) Branches, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Md; and the Department of Neurology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain (Drs Vendrell and Martinez).

Footnotes
Accepted for publication Oct 6, 1987.

Reprint requests to Experimental Therapeutics Branch, Bldg 10, Room 5C103, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892 (Dr Litvan).

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