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Karen A. Mello, MD; Bruce P. Abbott, MD

Arch Neurol. 1988;45(2):210-213.

Abstract
• Joseph's disease, an autosomal dominant, degenerative neurologic disease found in the Portuguese, is clinically manifested by extrapyramidal, pyramidal, and cerebellar dysfunction. A patient with the type II form of the disease reported improvement in gait and lessened spasticity while taking sulfamethoxazole and trimethoprim (Bactrim) for a noninfectious dysuria syndrome. A double-blind, placebo-controlled trial of Bactrim utilizing a subjective performance scale, physical examination, and six timed tests was performed in this patient. Results revealed lessened spasticity, improvement in walker-assisted gait, and correlative subjective responses. These results suggest an antispasticity effect of Bactrim or one of its components in this patient.

Author Affiliations
From the Departments of Medicine (Dr Mello) and Neurology (Dr Abbott), St Luke's Hospital, New Bedford, Mass.

Footnotes
Accepted for publication Sept 3, 1987.

Reprint requests to Greater New Bedford Community Health Center, 1204 Purchase St, New Bedford, MA 02740 (Dr Mello).

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