Seizure control with clomiphene therapy. A case report
A. G. Herzog
Neuroendocrine Section, Charles A. Dana Research Institute, Beth Israel Hospital, Boston, MA 02215.
Clinical seizures ceased during six months of clomiphene citrate therapy in
a 36-year-old man who had hypogonadotropic hypogonadism, reproductive
dysfunction, and a 16-year history of regular seizures. Seizures recurred
during the month that followed the discontinuation of clomiphene therapy.
This apparent antiseizure effect of clomiphene is discussed in terms of
three possible mechanisms of action: (1) Clomiphene may benefit seizures by
raising serum levels of antiseizure medications. (2) Clomiphene may improve
seizures by normalizing serum testosterone levels. (3) Clomiphene may act
at a cerebral level to lessen seizures. A controlled investigation of the
effects of clomiphene on epilepsy in the setting of reproductive
dysfunction is suggested.
