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H. Kalervo Väänänen, MD, PhD; Timo E. S. Takala, MD, PhD; Uolevi Tolonen, MD, PhD; Juhani Vuori, MSc; V. V. Myllylä, MD, PhD

Arch Neurol. 1988;45(11):1254-1256.

Abstract
• Serum concentration of carbonic anhydrase III (S-CA III), a novel marker of type I skeletal muscle cells was measured in 37 patients with neuromuscular diseases (polymyositis, muscular dystrophies, amyotrophic lateral sclerosis, and other neurogenic diseases) and in 24 control patients. Signficant elevation in S-CA III was observed in all patient groups. Serum concentration of carbonic anhydrase III correlated positively with serumcreatine kinase. Serum concentration of carbonic anhydrase III was observed to be a more sensitive skeletal muscle marker both in myogenic and in neurogenic muscle affecting diseases than serum creatine kinase.

Author Affiliations
From the Departments of Anatomy (Dr Väänänen), Neurology (Drs Tolonen and Myllylä), University of Oulu, and the Deaconess Institute of Oulu (Dr Takala and Ms Vuori), Oulu, Finland.

Footnotes
Accepted for publication June 21, 1988.

Reprint requests to Department of Neurology, University of Oulu, SF-90220 Oulu, Finland (Dr Myllylä).

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