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Improvement of Cerebellar Ataxia With Levorotatory Form of 5-HydroxytryptophanA Double-blind Study With Quantified Data Processing
Paul Trouillas, MD;
Frédérique Brudon, MD;
Patrice Adeleine, PhD
Arch Neurol. 1988;45(11):1217-1222.
Abstract
Some features of cerebellar ataxia have been reported to regress partially with long-term administration of 5-hydroxytryptophan or levorotatory form of 5-hydroxytryptophan. To test this effect further, 30 patients with various inherited or acquired cerebellar ataxias underwent a randomized, double-blind trial of placebo, and the levorotatory form of 5-hydroxytryptophan taken orally for four months. The levorotatory form of 5-hydroxytryptophan significantly improved the ataxia score. It also significantly modified the time of standing upright, the spread of feet, the speed of walking, speaking, and writing. In five cases in which the levorotatory form of 5-hydroxytryptophan therapy was maintained for 12 months, the effect continued progressively.
Author Affiliations
From the Neurology Service and Ataxia Research Center, Hôpital Neurologique, Alexis Carrel Faculty of Medicine, Lyon, France.
Footnotes
Accepted for publication March 21, 1988.
Reprint requests to Service de Neurologie, Hôpital Neurologique, 59 Blvd Pinel, 69003 Lyon, France (Dr Trouillas).
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