Slowing of Cognitive Processing in Progressive Supranuclear Palsy: A Comparison With Parkinson's Disease

doi:10.1001/archneur.1988.00520350032011

You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.

Vol. 45 No. 11, November 1988

Online Only
	•	Online First Table of Contents

ORIGINAL CONTRIBUTIONS

•	Online Features

This Article
•	References
•	Full text PDF
•	Reply to article
•	Send to a friend
•	Save in My Folder
•	Save to citation manager
•	Permissions

Citing Articles
•	Citation map
•	Citing articles on HighWire
•	Citing articles on Web of Science (110)
•	Contact me when this article is cited

Related Content
•	Similar articles in this journal

Social Bookmarking
	What's this?

Slowing of Cognitive Processing in Progressive Supranuclear Palsy

A Comparison With Parkinson's Disease

Bruno Dubois, MD; Bernard Pillon, PhD; Françoise Legault, MS; Yves Agid, MD, PhD; François Lhermitte, MD

Arch Neurol. 1988;45(11):1194-1199.

Abstract

• To investigate central processing time in patients withprogressive suprancuclear palsy and Parkinson's disease, reactiontimes were measured using tasks with different levels of cognitivecomplexity but with the same motor response. In patients withParkinson's disease, the additional central processing timerequired for more complex situations was no different from thatin control subjects, suggesting that cognitive aspects of thereaction time procedures tested were possibly too simple toreveal a slowing of thought processes in these patients. Comversely,the central processing time was increased in patients with progressivesupranuclear palsy compared with both Parkinson's disease andcontrol subjects. The increase was associated with impairmentin frontal lobe test performance. These results confirm thata slowing of central processing is a prominent feature of thecognitive disturbances of progressive supranuclear palsy and,furthermore, suggest that this slowing may be related to striatofrontaldysfunction.

Author Affiliations

From the Clinique de Neurologie et Neuropsychologie and INSERM U289, Paris.

Footnotes

Accepted for publication Feb 22, 1988.

Reprints not available.

Add to CiteULike CiteULike Add to Connotea Connotea Add to Delicious Delicious Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Cognitive impairment in patients with multiple system atrophy and progressive supranuclear palsy
Brown et al.
Brain 2010;133:2382-2393.
ABSTRACT | FULL TEXT

Response slowing in Parkinson's disease: A psychophysiological analysis of premotor and motor processes
Low et al.
Brain 2002;125:1980-1994.
ABSTRACT | FULL TEXT

Pathophysiology of bradykinesia in Parkinson's disease
Berardelli et al.
Brain 2001;124:2131-2146.
ABSTRACT | FULL TEXT

Performance on the PD test battery by relatives of patients with progressive supranuclear palsy
Baker and Montgomery
Neurology 2001;56:25-30.
ABSTRACT | FULL TEXT

Neuropsychological consequences of chronic bilateral stimulation of the subthalamic nucleus in Parkinson's disease
Saint-Cyr et al.
Brain 2000;123:2091-2108.
ABSTRACT | FULL TEXT

Neuropsychological follow up in patients with Parkinson's disease, striatonigral degeneration-type multisystem atrophy, and progressive supranuclear palsy
Soliveri et al.
J. Neurol. Neurosurg. Psychiatry 2000;69:313-318.
ABSTRACT | FULL TEXT

Physiological, pharmacological and neurohormonal assessment of autonomic function in progressive supranuclear palsy
Kimber et al.
Brain 2000;123:1422-1430.
ABSTRACT | FULL TEXT

Classic diseases revisited: Progressive supranuclear palsy (Steele-Richardson-Olszewski disease)
Morris et al.
Postgrad. Med. J. 1999;75:579-584.
ABSTRACT | FULL TEXT

Explicit Memory in Alzheimer's, Huntington's, and Parkinson's Diseases
Pillon et al.
Arch Neurol 1993;50:374-379.
ABSTRACT

Effects of Physostigmine on Spatial Attention in Patients With Progressive Supranuclear Palsy
Kertzman et al.
Arch Neurol 1990;47:1346-1350.
ABSTRACT

Positron Emission Tomography Study in Progressive Supranuclear Palsy: Brain Hypometabolic Pattern and Clinicometabolic Correlations
Blin et al.
Arch Neurol 1990;47:747-752.
ABSTRACT

Frontal Lobe Function in Progressive Supranuclear Palsy
Grafman et al.
Arch Neurol 1990;47:553-558.
ABSTRACT

| | |