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Gary A. Rosenberg, MD; Otto Appenzeller, MD, PhD

Arch Neurol. 1988;45(10):1104-1106.

Abstract
• In a double-blind placebo-controlled crossover study of ten patients with multiple sclerosis, we found amantadine hydrochloride therapy to be effective in improving fatigability in six. Administration of the drug was associated with significantly higher levels of β-endorphinβ-lipotropin and responders had significantly higher levels than nonresponders. Lactate levels were significantly higher and pyruvate levels lower in nonresponders. Amantadine given for fatigue to patients with multiple sclerosis is associated with measurable changes in levels of metabolites and peptides in the circulation.

Author Affiliations
From the Departments of Neurology (Drs Rosenberg and Appenzeller) and Medicine (Dr Appenzeller), University of New Mexico School of Medicine, and the Neurology Service, Veterans Administration Medical Center (Dr Rosenberg), Albuquerque.

Footnotes
Accepted for publication May 6, 1988.

Presented in part at the 39th Annual Meeting of the American Academy of Neurology, New York, April 7, 1987.

Reprint requests to the Department of Neurology, University of New Mexico School of Medicine, Albuquerque, NM 87131 (Dr Appenzeller).

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