You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.


ABOUT ARCHIVES
Advanced Search

Welcome   | My Account | E-mail Alerts | Access Rights | Sign In


  Vol. 45 No. 10, October 1988 TABLE OF CONTENTS
  Archives
  •  Online Features
  ARTICLE
 This Article
 • Reply to article
 •Send to a friend
 • Save in My Folder
 •Save to citation manager
 •Permissions
 Citing Articles
 •Citing articles on HighWire
 •Contact me when this article is cited
 Related Content
 •Similar articles in this journal

Amantadine, fatigue, and multiple sclerosis

G. A. Rosenberg and O. Appenzeller
Department of Neurology, University of New Mexico School of Medicine, Albuquerque 87131.

In a double-blind placebo-controlled crossover study of ten patients with multiple sclerosis, we found amantadine hydrochloride therapy to be effective in improving fatigability in six. Administration of the drug was associated with significantly higher levels of beta-endorphin-beta-lipotropin and responders had significantly higher levels than nonresponders. Lactate levels were significantly higher and pyruvate levels lower in nonresponders. Amantadine given for fatigue to patients with multiple sclerosis is associated with measurable changes in levels of metabolites and peptides in the circulation.

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Origin of Fatigue in Multiple Sclerosis: Review of the Literature
Kos et al.
Neurorehabil Neural Repair 2008;22:91-100.
ABSTRACT  

A Randomized Controlled Trial of Cognitive Behavior Therapy for Multiple Sclerosis Fatigue
van Kessel et al.
Psychosom. Med. 2008;70:205-213.
ABSTRACT | FULL TEXT  

Treating fatigue in patients with MS: One step forward, one step back
Schwid and Murray
Neurology 2005;64:1111-1112.
FULL TEXT  

Cardiovascular autonomic dysregulation and fatigue in multiple sclerosis
Merkelbach et al.
Mult Scler 2001;7:320-326.
ABSTRACT  





HOME | CURRENT ISSUE | PAST ISSUES | TOPIC COLLECTIONS | CME | SUBMIT | SUBSCRIBE | HELP
CONDITIONS OF USE | PRIVACY POLICY | CONTACT US | SITE MAP
 
© 1988 American Medical Association. All Rights Reserved.