You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.


ABOUT ARCHIVES
Advanced Search

Welcome   | My Account | E-mail Alerts | Access Rights | Sign In


  Vol. 45 No. 10, October 1988 TABLE OF CONTENTS
  Archives
  •  Online Features
  ARTICLE
 This Article
 • Reply to article
 •Send to a friend
 • Save in My Folder
 •Save to citation manager
 •Permissions
 Citing Articles
 •Citing articles on HighWire
 •Contact me when this article is cited
 Related Content
 •Similar articles in this journal

Correlation of phosphorus-31 magnetic resonance spectroscopy and morphologic findings in Alzheimer's disease

J. W. Pettegrew, K. Panchalingam, J. Moossy, J. Martinez, G. Rao and F. Boller
Department of Psychiatry, University of Pittsburgh, PA.

Senile plaques (SPs), especially, and neurofibrillary tangles are important pathologic markers for the diagnosis of Alzheimer's disease (AD), but neither is pathognomonic for AD. We hypothesize that elevations in levels of phosphomonoesters, precursors of membrane phospholipids, occur early in the pathogenesis of AD and precede the appearance of SPs. In contrast, elevations in levels of phosphodiesters, breakdown products of phospholipids, reflect degeneration of neural membranes and will correlate with the appearance of SPs. Correlative phosphorus-31 magnetic resonance spectroscopy and morphologic studies conducted to test this hypothesis disclosed that elevations in levels of phosphomonoesters had a negative correlation with the numbers of SPs, and elevations in levels of phosphodiesters had a positive correlation with the numbers of SPs. No correlations were observed for either membrane parameter and neurofibrillary tangles. These findings support our hypothesis and suggest that aberrations in the synthesis of membrane phospholipids are early metabolic events in the pathogenesis of AD.

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

MR spectroscopy of brain white matter in the prediction of dementia
den Heijer et al.
Neurology 2006;66:540-544.
ABSTRACT | FULL TEXT  

Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy in Dementias
Hsu et al.
J Geriatr Psychiatry Neurol 2001;14:145-166.
ABSTRACT  

Magnetic resonance spectroscopy in AD
Valenzuela and Sachdev
Neurology 2001;56:592-598.
ABSTRACT | FULL TEXT  

Phosphocreatine-dependent Glutamate Uptake by Synaptic Vesicles. A COMPARISON WITH ATP-DEPENDENT GLUTAMATE UPTAKE
Xu et al.
J. Biol. Chem. 1996;271:13435-13440.
ABSTRACT | FULL TEXT  





HOME | CURRENT ISSUE | PAST ISSUES | TOPIC COLLECTIONS | CME | SUBMIT | SUBSCRIBE | HELP
CONDITIONS OF USE | PRIVACY POLICY | CONTACT US | SITE MAP
 
© 1988 American Medical Association. All Rights Reserved.