Failure of antiviral therapy for acquired immunodeficiency syndrome-related cytomegalovirus myelitis
M. A. Jacobson, J. Mills, J. Rush, J. J. O'Donnell, R. G. Miller, C. Greco and M. F. Gonzales
Department of Medicine, University of California, San Francisco.
We report the first published case (to our knowledge) of
histopathologically documented acquired immunodeficiency syndrome-related
cytomegalovirus (CMV) myelitis in which antiviral drug therapy was
administered. Despite sensitivity of the patient's CMV isolate to therapy
with both ganciclovir and foscarnet, use of neither of these agents halted
progression of central nervous system CMV disease. Higher doses of these
drugs or combination therapy may be required to treat acquired
immunodeficiency syndrome-related CMV myelitis effectively.
