You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you can do to make your experience on this site better.


ABOUT ARCHIVES
Advanced Search

Welcome   | My Account | E-mail Alerts | Access Rights | Sign In


  Vol. 45 No. 1, January 1988 TABLE OF CONTENTS
  Archives
  •  Online Features
  ARTICLE
 This Article
 • Reply to article
 •Send to a friend
 • Save in My Folder
 •Save to citation manager
 •Permissions
 Citing Articles
 •Citation map
 •Citing articles on HighWire
 •Contact me when this article is cited
 Related Content
 •Similar articles in this journal

Brain glucose metabolism in neurologically normal patients with sickle cell disease. Regional alterations

G. P. Rodgers, C. M. Clark, S. M. Larson, S. I. Rapoport, A. W. Nienhuis and A. N. Schechter
Laboratory of Chemical Biology, NIDDK, Bethesda, MD 20892.

Neurologic dysfunction is a significant source of morbidity and mortality in the sickle cell diseases, occurring with a prevalence of 6% to 34%. Because changes in brain glucose metabolism may precede gross functional or morphologic alterations, we recently applied the technique of positron emission tomography with fluorodeoxyglucose F 18 in an exploratory study to compare six patients with sickle cell disease without prior neurologic abnormalities (and with normal cranial computed tomographic scans) with six healthy age-matched controls, with respect to overall and regional cerebral metabolic rates for glucose. We found no significant difference in the global metabolic rates for the two groups. However, we observed an unusual clustering of abnormal regional cerebral metabolic rates for glucose in the frontal lobes of these subjects. These results support previous observations that frontal lobe involvement may be quite prevalent in sickle cell disease, even among individuals with normal computed tomographic scans.

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Transcranial Doppler Ultrasonography and Neurocognitive Functioning in Children With Sickle Cell Disease
Kral et al.
Pediatrics 2003;112:324-331.
ABSTRACT | FULL TEXT  

Sickle Cell Disease: Continuous Arterial Spin-labeling Perfusion MR Imaging in Children
Oguz et al.
Radiology 2003;227:567-574.
ABSTRACT | FULL TEXT  

Sickle Cell and the Brain
Adams et al.
ASH Education Book 2001;2001:31-46.
ABSTRACT | FULL TEXT  

Cerebral Vasculopathy in Sickle Cell Anemia: Diagnostic Contribution of Positron Emission Tomography
Powars et al.
Blood 1999;93:71-79.
ABSTRACT | FULL TEXT  





HOME | CURRENT ISSUE | PAST ISSUES | TOPIC COLLECTIONS | CME | SUBMIT | SUBSCRIBE | HELP
CONDITIONS OF USE | PRIVACY POLICY | CONTACT US | SITE MAP
 
© 1988 American Medical Association. All Rights Reserved.