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F. Jacob Huff; Francois Boller, MD, PhD; Federica Lucchelli, MD; Richard Querriera, PA-C; Julia Beyer, MS; Steven Belle, PhD

Arch Neurol. 1987;44(9):929-932.

Abstract
• Abnormal findings on a standardized neurologic examination were compared between patients with a clinical diagnosis of probable Alzheimer's disease (AD) and healthy control subjects. Aside from mental status findings, the most useful examination findings for differentiating AD from control subjects were the presence of release signs, olfactory deficit, impaired stereognosis or graphesthesia, gait disorder, tremor, and abnormalities on cerebellar testing. These abnormalities probably reflect the different areas of the central nervous system that are affected pathologically in AD. In the clinical diagnosis of AD, particular attention should be given to these aspects of the neurologic examination.

Author Affiliations
From the Departments of Neurology (Drs Huff and Boller), Psychiatry (Drs Huff and Boller), and Epidemiology (Ms Beyer and Dr Belle), and the Pittsburgh Alzheimer's Disease Research Center (Drs Huff, Boller, Lucchelli, Belle and Mr Querriera and Ms Beyer), University of Pittsburgh.

Footnotes
Accepted for publication June 8, 1987.

Reprint requests to Alzheimer's Disease Research Center, Suite 400, Iroquois Building, 3600 Forbes Ave, Pittsburgh, PA 15213 (Dr Huff).

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