 |
|
Cerebrospinal Fluid Immunoglobulins and β2-Microglobulin in Lymphoproliferative and Other Neoplastic Diseases of the Central Nervous System
Jan Ernerudh, MD, PhD;
Tomas Olsson, MD, PhD;
Gösta Berlin, MD, PhD;
Henning von Schenck, MD, PhD
Arch Neurol. 1987;44(9):915-920.
Abstract
• Humoral immune aberrations may occur in the cerebrospinal fluid (CSF) of patients with lymphoproliferative and other neoplastic diseases infiltrating the central nervous system (CNS). Such aberrations may be of diagnostic importance. We therefore studied CSF and serum from 47 patients with lymphoproliferative diseases and from 16 patients with various nonlymphoid neoplasias; 17 patients and 12 patients, respectively, had neoplastic CNS involvement. Elevated CSF IgM index and oligoclonal IgG bands in CSF and serum were commonly found, especially in patients with CNS involvement. Cerebrospinal fluid IgG and IgA indexes were usually normal. Increased CSF to serum albumin ratio, reflecting blood-brain barrier dysfunction, and increased CSF β2-microglobulin concentration were most common in patients with CNS involvement. The results indicate that neoplastic CNS disease should be borne in mind when CSF humoral immune aberrations are found.
Author Affiliations
From the Departments of Neurology (Dr Ernerudh), Internal Medicine (Dr Berlin), and Clinical Chemistry (Dr von Schenck), University Hospital, Linköping (Sweden), and the Department of Neurology (Dr Olsson), Karolinska Institute, Huddinge (Sweden) Hospital.
Footnotes
Accepted for publication March 30, 1987.
Reprint requests to Department of Neurology, University Hospital, S-58185, Linköping, Sweden (Dr Ernerudh).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
CSF Antithrombin III and Disruption of the Blood-Brain Barrier
Zetterberg et al.
JCO 2009;27:2302-2303.
FULL TEXT
Topical Review: A Review of Leptomeningeal Metastases in Pediatrics
Chamberlain
J Child Neurol 1995;10:191-199.
ABSTRACT
|
